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《Journal of Clinical Rational Drug Use》 2011-29
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Explore the Effection and Machanism of Different Doses of Ulinastatin in Septic

CHEN Xiao-bing,XU Tie,LI Xiao-min,et al.Center of Emergency,First People's Hospital of Lianyungang,Affiliated Hospital Xuzhou Medical College,Lianyungang 222001,China  
Objective To observe the changes of tumor necrosis factor-a(TNF-a)、inter-leukin-6(IL-6)in plasma and the expression of nuclear factor-KappaB(NF-κB)in lungs in rabbits with septic shock induced by endotoxin,and to explore the prote-ctive the effection and mechanism of different doses of Ulinastatin(UTI).Methods 50 male Japanese flap-eared white rabbits were randomly divided into 5 groups:Endotoxin induced septic shock control group(group con),Dexamethasone treated group(group DXM),(2.5×104)u/kgUTI treated groups(group U1)、(5.0×104)u/kgUTI treated groups(group U2)and(10.0×104)u/kgUTI treated grou-ps(group U3).Septic shock models of the rabbits were replicated by intravascularET injection(2mg/kg).Then 0.9% physiological saline(2.0ml),DXM(1.0mg/kg),and UTI in doses of(2.5×104)U/kg、(5.0×104)U/kg,and(10.0×104)U/kg were respectivel-y given in 2.0ml 0.9% physiological saline after the septic shock models wereset up.At oh after shock and 2h、4h、6h、12h after treated,The changes of me-an arterial blood pressure(MAP)and Respiratory Rate(RR)were determined,The levels of TNF-a and IL-6 in plasma of the rabbits were measured by using E-LISA;The morphological changes of lungs were observed under microscope,The expression and distribution of NF-κB in rabbits'lungs were detected by immun-ohistochemistry.Results The levels of MAP、RR and TNF-a、IL-6 at oh after the septic shock showed not significant difference among the five groups,however,the levels of MAP、RR and TNF-a、IL-6 at 2h、4h、6h、12h in the three UTI group were significant decreased as compared with group con and group DXM(P0.05),and group U3 were lower than group U1 and group U2(P0.05);The mor-phological changes of lungs in group Con were the most obvious,group U3 wer-e the lightest as compared with other groups(P0.05).The expression of NF-κB in group Con was the most obvious,groupU3 was the lightest as compared wi-th other groups(P0.05).The leveles of MAP、RR and TNF-a、IL-6 and the ex-pression of NF-κB were degraded with the increasing doses of UTI(P0.05).Conclusion UTI can improve the changes of MAP、RR and TNF-a、IL-6 in septic shock induced dy ET in rabbits and the lung protective function is the positive correlation with the dosage.Inhibiting NF-κB signal transduction pathwa-ys to inhibit the expression of TNF-a and IL-6 is one of UTI lung protective function important mechanisms.
【CateGory Index】: R965
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 JIANG Jing-jing,SHI Xue-yin,YUAN Hong-bin,ZHU Qiu-feng,WANG Cheng-cai,SUN Hai-jing.Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Effects of ulinastatin on NF-κB expression in lung tissue of rats with acute lung injury[J];Medical Journal of Chinese People's Liberation Army;2009-05
2 JIANG Long-yuan YANG Lian-hong CHANG Jian-xing HE Zhi-jiang YU Tao HUANG Zi-tong Department of Emergency,the Second Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,China;The effect of Ulinastatin on the delivery of cytokines in patients with septic shock[J];Chinese Journal of Emergency Medicine;2006-12
3 LIANG Xiao-zhong~1,YAO Hua-guo~2,ZHANG Yuan-Li~2.(1.GuangDong Medical College,Zhanjian,524001,China;2.ICU,The Affiliated Hospital of GuangDong Medical College,GuangDong 524001,China);Progress about Organ Protection of Ulinastatin in Sepsis[J];Medical Recapitulate;2006-16
4 SHAO Yiming, ZHANG Liangqing, DENG Liehua, YAO Huaguo. Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China;Clinical study on effects of ulinastatin on patients with systemic inflammatory response syndrome[J];Chinese Critical Care Medicine;2005-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Zi-jun,CUI Ming,JIANG Yong,ZUO YAN-qing (Tongling People's Hospital,Tongling,Anhui 244009,China);Therapeutic value of ulinastatin in acute severe traumatic craniocerebral injury[J];Anhui Medical and Pharmaceutical Journal;2009-10
2 WANG Chun-hua,HU De-lin,YU You-xin,FANG Lin-sen,XU Qing-lian,WANG Chang-rong (Burn Department,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China);Clinical effects of ulinastatin in patients with severe burn sepsis[J];Anhui Medical and Pharmaceutical Journal;2010-11
3 ;Effect of ulinastatin on inflammation reaction and protection of lung during cardiopulmonary bypass in infants[J];Academic Journal of Second Military Medical University;2008-07
4 LIU Chang-hai1,2,SUN Shao-hua3,LI Hai-ling4,ZHANG Wei-hua51.Preclinical Medical College,Lanzhou University,Lanzhou 73000,China2.Department of Forensic Medicine,Inner Mongolian Medicine College,Hohhot 0100593.Pathological Institute,the First Hospital of Lanzhou University,Lanzhou 7300004.Department of Preventive Medicine,Inner Mongolian Medicine College,Hohhot 0100595.Aqi Public Security Bureau of Chifeng City,Chifeng 025571;Regulatory effect of ulinastatin on NF-κB and MMP-2/TIMP-2 in rats with acute renal trauma[J];Academic Journal of Second Military Medical University;2008-10
5 YANG Hong-guang,LI Feng,YOU Shu-hong,XU Fang-lin,ZOU Ting,LUO Yun(Department of ICU,the First People Hospital of Jiujiang,Jiujiang 332000,Jiangxi,China);Clinical observation of 53 cases with multiple organ dysfunction syndrome treated with ulinastatin combines with continuous veno-venous hemofiltration[J];Military Medical Journal of Southeast China;2008-03
6 LIN Sen, LUO Xiang-Xiang, LIU Song-Ping Department of Surgery, Hainan Provincial 3rd People's Hospital, Sanya 572000, China;Ulinastin in treatment of acute pancreatitis[J];Journal of the Fourth Military Medical University;2008-16
7 XU Li,LE Sheng. Department of Emergency Trauma Center,Huizhou Municipal Central Hospital,Huizhou 516001,China;The effect of ulinastatin for the treatment severe multiple trauma[J];Guangdong Medical Journal;2009-04
8 YE Jue-ming,FENG Qi-ming,TAO Bao-hua (Department of Emergency,Shanghai No.6 People’s Hospital,Shanghai Jiao Tong University,Shanghai 200233,China);Clinical efficacy of ulinastain in heat stroke[J];World Clinical Drugs;2009-03
9 ZHAO Ying1,ZHANG Yan-fang1,LONG Chao-liang1,CUI Wen-yu1,PAN Zhi-yuan1,WANG Hai1,2(1.Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China;2.Institute of Hygiene and Environmental Medicine,Academy of Military Medical Sciences,Tianjin 300050,China);Effects of iptakalim on renal injury induced by lipopolysaccharide,oleic acid and diethylene glycol[J];Journal of International Pharmaceutical Research;2010-01
10 LIU Tao,DU Ping,LIANG Zhonghui(PLA 303 Hospital,Guangxi Nanning 530021,China);The Effect of Ulinastatin in Treatment of Acute Pancreatitis and its Complications[J];Hebei Medicine;2011-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LI Qi, QIAN Gui sheng, ZHANG Qing, WANG Chang zheng (Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effects of different doses of lipopolysaccharide on acute lung injury in rats[J];Acta Academiae Medicinae Militaris Tertiae;2004-10
2 QIAN Gui-sheng. Institute of Respiatory Disease of PLA,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;Recent progress in research on the diagnosis and treatment of acute lung injury and acute respiratory distress syndrome[J];Medical Journal of Chinese People's Liberation Army;2009-04
3 QIU Haibo,ZHOU Shaoxia,YANG Yi,et al.Department of Critical Care Medicine and Emergency,ZhongDa Hospital,Southeast University,Nanjing 210009;Multiple organ dysfunction syndrome:predictors of mortality and clinical therapeutic strategies.[J];Journal of Emergenoy Medicine;2001-01
4 QIAO Wanhai,PEI Honghong,LI Xiaozhen,et al.Department of Emergency,The Second Hospital of Xian Jiao Tong University,Xian 710004,China;Changes and clinical significance of plasma cytokines in critically ill patients[J];Journal of Emergency Medicine;2003-02
5 Guo Zhenghui,Hong Xin,Mao Baoling,et al.Department of Instisute of Respiratory Disease,Xingqiao Hospital,Third Military Medical University,Chongqing 400037,China [;Effects of nuclear factor-κB activation on acute lung injury[J];Journal of Emergency Medicine;2003-09
6 Li Xiujiang,Du Yujun, Wang Liping. Emergency Department,The First Hospital of Jilin University, Changchun 130021,China;The renal protective effects of ulinastatin in rats with multiple organ dysfunction syndrome[J];Chinese Journal of Emergency Medicine;2006-06
7 FANG Qiang, CHEN Pu.(Department of ICU,The First Affiliated Hospital Zhejiang University,School of Medicine,Hangzhou310003,China);A Study on clinical efficacy of ulinastatin in severe sepsis patients and its mechanism of action[J];Chinese Journal of Infection and Chemotherapy;2005-01
8 Peng Wan-yong,Cheng Yang-long,Peng Ai-fang,Zheng Qi-changDepartment of Trauma,Union Hospital,Tonji Medical College,Huazhong University of Science and Technology,Wuhan 430022;Experimental Study on the Role of Urinary Trypsin Inhibitor (UTI) in Pancreatic Wound-healing of the Rat[J];Chinese Journal of Clinical Gastroenterology;2003-04
9 ZHANG Hua-fang 1,LI Yi-zhao 2 ( 1Weifang People's Hospital,Weifang 261042,China; 2Shandong College Qilu Hospital);Experimental Study of Ulinastatin on the Protection of Cerebral Ischemia Injury[J];Acta Academiae Medicinae Weifang;2003-05
10 JIA Hui,LIU Zhiyong. Department of Thoracic Surgery,Jiangsu Cancer Hospital,Nanjing 210009,CHINA;Protective effects of ulinastatin on renal ischemia-reperfusion injury[J];Jiangsu Medical Journal;2005-03
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