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《Chinese Journal of Current Advances in General Surgery》 2011-01
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Protective effect of puerarin on cardiac insufficiency during liver is chemia-reperfusion injury in rats

SHAO Ya-fang1,XU Qun1,SHENG Yan-yan1,WANG Xu-lin2,WANG Hong-mei3,ZHAO Chuan-chang4,WU Zhong-min5 1Medical College of Taizhou University(Taizhou 318000,China) 2Department of Oncological Surgery,Taizhou Municipal Hospital(Taizhou 318000,China) 3Department of Pathphysiology,4Centre of Experimentation,5Anatomy Section,Medical College of Taizhou University(Taizhou 318000,China)  
Objective: To explore protective effect of puerarin on cardiac insufficiency following liver ischemia-reperfusion injury.Methods: A model of liver ischemia-reperfusion injury was established by imitation.Thirty-two healthy rats were randomly divided as following(n=8): the control group(the group of sham operation),reperfusion following ischemia 30 min(I/R group),puerafin pretreatment group(PUE group),normal saline pretreatment group(N group).HR,LVSP,LVEDP,+dp/dtmax,-dp/dtmax,endotoxin and MPO were observed.Results: HR was no significant statistics between I/R group and N group(P0.05),and increased in PUE group and N group,compared with I/R group.The contents of LVSP,LVEDP and +dp/dtmax were significantly decreased between I/R group and N group(P0.05),remarkable increasing in PUE group(P0.01),the contents of LVEDP,-dp/dtmax were significantly decreased in PUE group,compared with I/R and N group.Endotoxin levels and MPO were significantly increased between I/R group and N group(P0.05),remarkable decreasing in PUE group(P0.05),but no significant statistics between PUE group and N group(P0.05).Conclusion: Cardiac insufficiency may be induced following the process of liver ischemia-reperfusion injury,then puerafin pretreatment have an protect effect on cardiac insufficiency by decreasing endotoxin levels and MPO.
【Fund】: 浙江省2008大学生“新苗人才计划”基金(2008R40G2170048)
【CateGory Index】: R285.5
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