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《Chinese Journal of Current Advances in General Surgery》 2011-11
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Changes and significance of immune function in hepatitis patients with liver cirrhosis and ascites before and after fresh frozen plasma transfusion

CHEN Zhao-xiu1,XU Jian-min2,WANG Xiao-cui1,LI Ai-guo1,TIAN Xiang-ping2,YANG Huan-dong3 The Wei Fang Yi Du Center Hospital,1Blood Transfusion Department,2Gestroenterology,3General Surgery Department(Shandong Qingzhou,262500)  
Objective: To investigate the immune function changes and its significance in hepatitis patients with liver cirrhosis and ascites before and after fresh frozen plasma transfusion.Methods: 86 hepatitis patients with liver cirrhosis and ascites were randomly divided into general treatment group and fresh frozen plasma transfusion group.Serum IgG,IgM,IgA and complement C3,C4 level were detected and T cell subsets in peripheral blood were detected by flow cytometry in both group before and after treatment.Results: The Serum IgG,IgM,IgA level were signifcantly increased and complement C3,C4 level were signifcantly decreased in hepatitis patients with liver cirrhosis and ascites compared with control subjects.After treatment,The Serum IgG,IgM,IgA level were signifcantly decreased and complement C3,C4 level were signifcantly increased in general treatment group and fresh frozen plasma transfusion group.There was no statistical difference of Serum IgG,IgM,IgA level after treatment between both groups.But the complement C3,C4 level after treatment in plasma transfusion group were higher than those in general treatment group.Peripheral blood CD3,CD4 and CD4/CD8 ratio were also signifcantly decreased and CD8 was signifcantly increased in hepatitis patients with liver cirrhosis and ascites.After treatment,The CD3,CD4 and CD4/CD8 ratio were signifcantly increased and CD8 was signifcantly decreased in general treatment group and fresh frozen plasma transfusion group.The CD3,CD4 and CD4/CD8 ratio after treatment in plasma transfusion group were significantly higher than those in general treatment group.Conclusion: Fresh frozen plasma transfusion can improve the cellular and humoral immune function in hepatitis patients with liver cirrhosis and ascites.
【Fund】: 潍坊市卫生局科研项目(2011-014)
【CateGory Index】: R575.2
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