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《Chinese Journal of Evidence-Based Cardiovascular Medicine》 2012-03
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Treatment of acute ST-segment elevation myocardial infarction with low-dose intra-coronary injection of tirofiban combining thrombus aspiration

LI Jun-xia, GUO Jie, HAN Sha-sha, LI Li-chong, ZHANG Jian, WANG Shi-hong, SHI Yu-jie. Department of Cardiovasology, General Hospital of PLA Beijing Military Area Command, Beijing 100700, China.  
Objective To review the influences of low-dose intra-coronary or intra-vein injection of tirofiban combining thrombus aspiration on the infarction-related vascular flow and prognosis in the patients with ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI). Methods The patients (n=133) diagnosed STEMI and accepted direct PCI were selected and randomly divided into treatment group [treated with low-dose intra-coronary or intra-vein injection of tirofiban-the antagonist of platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) combining thrombus aspiration, n=67] and control group (treated with routine PCI combining high-dose intra-vein injection of tirofiban, n=66). The blood flow grading of TIMI of infarction-related vascular before and after PCI, myocardial perfusion, major adverse cardiac events (MACE) within 90 days after PCI and bleeding complications after PCI were reviewed in two groups. Results The vascular patency rate was 100% in two groups. Compared with control group, the incidence of no reflow decreased, myocardial perfusion was relieved, and MACE within 90 days after PCI decreased in treatment group (2.9% vs. 12.1%, P0.05). The incidence of bleeding complications in perioperative period was not different between two groups. Conclusion The therapy of low-dose intra-coronary or intra-vein injection of tirofiban combining thrombus aspiration can effectively improve infarction-related vascular flow and prognosis in the patients with STEMI and its safety is higher.
【CateGory Index】: R542.22
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