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《Qianwei Journal of Medicine》 2004-02
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Clinical value of LAP, NAG and GPDA levels in urine of patients with chronic liver disease associated with HBV infection

ZHOU Xiumei, CAN Tianfu, ZHANG Yuqi, et al. The 88th Central Hospital of PLA, Taian 271000,China  
Objective To study the clinical value of enzymes (LAP, NAG and GPDA) levels in the urine of patients with chronic liver diseases associated with HBV infection. Methods (1)All the patients were divided into chronic hepatitis group, compensated liver cirrhosis group, decompensated liver cirrhosis group and the control group. LAP, NAG and GPDA levels in their urine were detected and statistical difference between each group was studied. (2) According to the degree of liver function damage, all the cases were divided into slight, moderate and severe liver function damage groups; LAP, NAG and GPDA levels in the urine between each group were compared.(3)According to HBV DNA quantity levels, all the cases were divided into lower duplication degree group and higher duplication degree group; LAP, NAG and GPDA levels in the urine were compared among them. Results (1)LAP, NAG and GPDA levels of compensated and decompensate liver cirrhosis were higher than that of chronic hepatitis and control group(P0.05 and P0.01),respectively. LAP, NAG and GPDA levels of decompensated liver cirrhosis was higher than that of compensated liver cirrhosis (P0.05).(2) Positive correlation among LAP, NAG and GPDA levels in urine and liver function damage degree can be found (P0.05 and P0.05).(3)No statistical difference was found between lower and higher duplication degree groups (P0.05). Conclusion The levels of LAP, NAG and GPDA in urine can be used as a sensitive index for indicating complicated renal damage in early stage for chronic liver diseases associated with HBV infection, and also indirectly indicating the damage of liver function. The levels of enzymes (LAP, NAG and GPDA) in urine have no correlation to the degree of HBV DNA duplication
【CateGory Index】: R512.62
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