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《Journal of Tsinghua University(Science and Technology)》 2004-09
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Application of isomap for cluster analyses of gene expression data

YUAN Yuan~1,2, JI Xinglai~1,3, SUN Zhirong~1,3, LI Yanda~1,2(1. Key Laboratory of Bioinformatics of the Ministry of Education, Tsinghua University, Beijing 100084, China; 2. Department of Automation, Tsinghua University, Beijing 100084, China; 3. Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China)  
The cluster analysis of gene expression data is an important means for discovering gene functions and regulatory mechanisms. A novel clustering algorithm based on isometric feature mapping (Isomap) was used to analyze large-scale gene expression data. The algorithm improved the distance measurement between samples by replacing the classical Euclidean distance with the geodesic distance, which helped preserve the intrinsic geometry of the high-dimensional data. Two public gene expression datasets were analyzed, with the results evaluated using a new method named Normalized Cut. The algorithm provides more useful information than other methods, with obvious biological meanings. The optimal cluster number can also be estimated by the method.
【Fund】: 国家自然科学基金资助项目 ( 60 2 3 40 2 0 ) ;; 科技部重大项目前期研究专项 ( 2 0 0 1CCA0 14 0 0 )
【CateGory Index】: TP301
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6 WANG Sheng-li, WANG Ke-xin(Department of Computer Science, Jinan University, Guangzhou 510632,China);Application of ISOMAP for Cluster Analyses Of Chinese Documents[J];Microcomputer Applications;2009-08
7 NI Yan(Istitute of Science,PLA University of Science and Technology,Nanjing 210007,P.R.C.);Nonlinear dimensionality reduction of Isomap in the analysis of seismic attribute parameter data[J];Journal of Southwest University for Nationalities(Natural Science Edition);2008-02
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【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LUO Xiao-jiang, HAN Jian-bao (National Keylab. of Vehicular Transmission,Beijing Institute of Technology,Beijing 100081,China);Pretreatment of the State Monitoring Data of Vehicle Transmission[J];Vehicle & Power Technology;2006-02
2 CHEN Shi-qiu,HAN Jian-bao,LUO Xiao-jiang(School of Mechanical & Vehicular Engineering,BeijingInstitute of Technology,Beijing 100081,China);Singularity Index Identification of Vehicle Transmission Faults Based on the Fuzzy Neural Network[J];Vehicle & Power Technology;2006-04
3 XIAO Cheng-lin,HAN Jian-bao,LUO Xiao-jiang(National Keylab.of Vehicular Transmission,Beijing Institute of Technology,Beijing 100081,China);Fault-feature Detection of Transmission System Based on Simulated Algorithm and Genetic Algorithm[J];Vehicle & Power Technology;2006-04
4 Song Guibao1,Yuan Hongwu2,Li Hongliang2(1.Dept.of Airborne Vehicle Engineering,Naval Aeronautical & Astronautical University,Yantai 264001,China; 2.Administrant Brigade of Postgraduate,Naval Aeronautical & Astronautical University,Yantai 264001,China);Effectiveness Evaluation of Terminal Guidance Radar of Anti-Ship Missile Based on Probability Analysis[J];Ordnance Industry Automation;2011-10
5 Liu Xing-Fang,Zheng Xiao-Dong,Xu Guang-Cheng,Wang Ling,and Yang Hao 1.Geophysical Department,Research Institute of Petroleum Exploration and Development,PetroChina Company,Ltd., Beijing 100083,China.;Locally linear embedding-based seismic attribute extraction and applications[J];应用地球物理(英文版);2010-04
6 LIANG Zhi - rui,CHEN Peng,SU Hai - feng(North China Electric Power University,Baoding 071003,China);Association rule mining in fault monitoring of power plant equipment[J];Electric Power Automation Equipment;2006-06
7 CHEN Hui1,3,LIN Qiang2,JIA Jing1,LI Lu-jun1(1.Department of Graduate Management,AFEA,Wuhan 430019,China;2.Department of Land-Based Early Warning Surveillance Equipment,AFEA,Wuhan 430019,China;3.Unit 95980 of PLA,Xiangyang 441021,China);Research on Theoretic System of Radar Site Optimisation Evaluation[J];Electronic Information Warfare Technology;2013-01
8 WANG Xin1,REN Ming-qiu2,GAO Feng3,TAO Hai-yin4 (1.PLA Unit 94981,Nanchang 331200,China;2.Department of Optics and Electronics,OrdnanceEngineering College,Shijiazhuang 050003,China;3.PLA Unit 93046,Shenyang 110141,China; 4.Staff Room of Artillery Nanchang Military Academy,Nanchang 330103,China);Analysis and consideration on combat effectiveness evaluation in radar EW[J];Information Technology;2011-07
9 ZHAN Qing,WANG Ya-dong (Bioinformatics Technology Research Center,Harbin Institute of Technology,Harbin 150001,China);Information entropy analysis of bases distribution in genome translation initiation and termination regions[J];Journal of Natural Science of Heilongjiang University;2011-05
10 SONG Gui-bao,YUAN Hong-wu,LI Hong-liang(Naval Aeronautical and Astronautical University,Yantai 264001,China);Effectiveness Evaluation Method of Terminal Guidance Radar of Anti-ship Missile in Electronic Jamming Conditions[J];Shipboard Electronic Countermeasure;2011-05
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