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《Journal of Tsinghua University(Science and Technology)》 2004-09
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Application of isomap for cluster analyses of gene expression data

YUAN Yuan~1,2, JI Xinglai~1,3, SUN Zhirong~1,3, LI Yanda~1,2(1. Key Laboratory of Bioinformatics of the Ministry of Education, Tsinghua University, Beijing 100084, China; 2. Department of Automation, Tsinghua University, Beijing 100084, China; 3. Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China)  
The cluster analysis of gene expression data is an important means for discovering gene functions and regulatory mechanisms. A novel clustering algorithm based on isometric feature mapping (Isomap) was used to analyze large-scale gene expression data. The algorithm improved the distance measurement between samples by replacing the classical Euclidean distance with the geodesic distance, which helped preserve the intrinsic geometry of the high-dimensional data. Two public gene expression datasets were analyzed, with the results evaluated using a new method named Normalized Cut. The algorithm provides more useful information than other methods, with obvious biological meanings. The optimal cluster number can also be estimated by the method.
【Fund】: 国家自然科学基金资助项目 ( 60 2 3 40 2 0 ) ;; 科技部重大项目前期研究专项 ( 2 0 0 1CCA0 14 0 0 )
【CateGory Index】: TP301
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【References】
Chinese Journal Full-text Database 7 Hits
1 HAN Jian-bao, LUO Xiao-jiang(School of Mechanical & Vehicular Engineering,Beijing Institute of Technology,Beijing 100081,China);Perspective of Tank Transmission Failure Symptom Prediction Based on Data Mining[J];Acta Armamentarll The Volume of Tank, Armored Vehicle and Engine;2005-04
2 YUAN Li-guo1,TANG Wu-lei2(1.Department of Mathematics,South China Agricultural University,Guangzhou 510642 China;2.Gudong Soft Park,Guangzhou 510663 China);The Research of Nonlinear Dimensionality Reduction with Isomap and C-Isomap[J];Computer Knowledge and Technology(Academic Exchange);2007-04
3 TAO Yong1,WEN Gui-hua2,QI Fei3(1.School of Information Engineering,Hubei Institute for Nationalities,Enshi 445000,China;2.Research Institute of Computer Application,South China University of Technology,Guangzhou 510640,China;3.School of Information Science and Egnineering,East China University of Science and Technology,Shanghai 200237,China);Application of Analogy Association Based on Outstanding Characteristic in Patent Strategic Analysis[J];Journal of Hubei Institute for Nationalities(Natural Science Edition);2007-04
4 QI Wei,LI Xi-hai,LIU Dai-zhi(The Second Artillery Institute of Engineering,Xi'an,710025);Pattern Recognition of Underground Nuclear Explosions and Natural Earthquakes Based on Isomap[J];Nuclear Electronics & Detection Technology;2008-02
5 SU Yuan-ying,DONG Chao-jun Institute of Information,Wuyi University,Jiangmen,Guangdong 529020,China;Study of TOD based on Isomap and K-means clustering algorithm[J];Computer Engineering and Applications;2010-27
6 WANG Sheng-li, WANG Ke-xin(Department of Computer Science, Jinan University, Guangzhou 510632,China);Application of ISOMAP for Cluster Analyses Of Chinese Documents[J];Microcomputer Applications;2009-08
7 NI Yan(Istitute of Science,PLA University of Science and Technology,Nanjing 210007,P.R.C.);Nonlinear dimensionality reduction of Isomap in the analysis of seismic attribute parameter data[J];Journal of Southwest University for Nationalities(Natural Science Edition);2008-02
China Proceedings of conference Full-text Database 1 Hits
1 Liu Cui-xiang ,Sun Yi-cai, Zhang Yan,Yu Ming Hebei University of Technology,Department of Information Engineering,Tianjin ,300130 Hebei University of Technology,School of Computer Science and Engineering,Tianjin,300130;Application of Polynomial Fuzzy Matching Based on Three Rulers in Face Recognition[A];[C];2006
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Yong, ZHANG Zhen-yong, YANG Lian-xing(Fudan University, ASIC & System State-Key Lab.,Shanghai 200433,China);An efficient methodology for the SoC design of wireless digital communication and its application in a WLAN IC design[J];Semiconductor Technology;2003-02
2 ZHANG Hong-yan ,ZHOU Guang-ming,NING Ke-yan (China North Vehicle Research Institute,Beijing 100072,China);The Study on State Monitor and Failure Diagnosis of Integrated Transmission System[J];Acta Armamentarll The Volume of Tank, Armored Vehicle and Engine;2004-03
3 Wang Shaoping\ Wang Zhanlin (Beijing University of Aeronautics and Astronautics,Dept.of Automatic Control);FAULT DIAGNOSIS OF HYDRAULIC PUMP BASED ON ARTIFICIAL NEURAL NETWORK[J];JOURNAL OF BEIJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS;1997-06
4 QU Wei, LIU Heping, ZHANG DezhengInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China;Fault diagnosis system based on ICA feature[J];Journal of University of Science and Technology Beijing;2006-07
5 CHEN Jie, PENG Zhi hong (Dept. of Automatic Control, Beijing Institute of Technology, Beijing100081, China);Military Application Perspectives of Bioinformatics[J];Journal of Beijing Institute of Technology;2002-03
6 Lu Yingbei, Zhang Zengfang (Departmentof Computer & Electrical Engineering,Guangxi Engineering & Technology University,5450 0 5) Cai Kungbao (Electrical Engineering College,Chongqing University 40 0 0 4 4 );ECG Signal Baseline Correction Method Based on Wavelet Transform[J];Beijing Biomedical Engineering;2000-04
7 CHEN Zhong-lin, LIU Zhi-ming, ZHOU Ji-liu (College of Electronic Information, Sichuan University, Chengdu, China);Face detection in color images with complex background[J];Journal of Chengdu University of Technology(Science & Technology Edition);2004-01
8 ZHOU Zhong-li~1,FENG Wen-xin~2,GONG Hao~1,YONG Zhi-quan~1,LIU Shu-gen~1 1.College of Information Management,Chengdu University of Technology,Chengdu 610059,China;2.Special School of Zhengzhou Industry & Trade,Zhengzhou 450007,China;Forecast of the energy consumption in China achieved through microwave neural network[J];Journal of Chengdu University of Technology(Science & Technology Edition);2005-05
9 LIAO Hai-bin 1 , XU Hong-zhang 2 (1. School of Electronic Information, Wuhan University, Wuhan, Hubei 430079, China; 2. Department of Computer Science, Huanghuai University, Zhumadian, Henan 463000, China);Gene expression data feature extraction based on discriminant principal component[J];Journal of Yanshan University;2010-05
10 L OU Yong- Hua,JIAO Bing- Hua* (Departm ent of Biochem istry and Molecular Biology,Departm ent of Basic Medicine, Second Military Medical U niversity,Shanghai 2 0 0 4 33,China);Cloning and induced expression of LIGHT in peripheral blood lymphoctye[J];Academic Journal of Second Military Medical University;2002-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LUO Xiao-jiang, HAN Jian-bao (National Keylab. of Vehicular Transmission,Beijing Institute of Technology,Beijing 100081,China);Pretreatment of the State Monitoring Data of Vehicle Transmission[J];Vehicle & Power Technology;2006-02
2 CHEN Shi-qiu,HAN Jian-bao,LUO Xiao-jiang(School of Mechanical & Vehicular Engineering,BeijingInstitute of Technology,Beijing 100081,China);Singularity Index Identification of Vehicle Transmission Faults Based on the Fuzzy Neural Network[J];Vehicle & Power Technology;2006-04
3 XIAO Cheng-lin,HAN Jian-bao,LUO Xiao-jiang(National Keylab.of Vehicular Transmission,Beijing Institute of Technology,Beijing 100081,China);Fault-feature Detection of Transmission System Based on Simulated Algorithm and Genetic Algorithm[J];Vehicle & Power Technology;2006-04
4 Song Guibao1,Yuan Hongwu2,Li Hongliang2(1.Dept.of Airborne Vehicle Engineering,Naval Aeronautical & Astronautical University,Yantai 264001,China; 2.Administrant Brigade of Postgraduate,Naval Aeronautical & Astronautical University,Yantai 264001,China);Effectiveness Evaluation of Terminal Guidance Radar of Anti-Ship Missile Based on Probability Analysis[J];Ordnance Industry Automation;2011-10
5 Liu Xing-Fang,Zheng Xiao-Dong,Xu Guang-Cheng,Wang Ling,and Yang Hao 1.Geophysical Department,Research Institute of Petroleum Exploration and Development,PetroChina Company,Ltd., Beijing 100083,China.;Locally linear embedding-based seismic attribute extraction and applications[J];应用地球物理(英文版);2010-04
6 LIANG Zhi - rui,CHEN Peng,SU Hai - feng(North China Electric Power University,Baoding 071003,China);Association rule mining in fault monitoring of power plant equipment[J];Electric Power Automation Equipment;2006-06
7 CHEN Hui1,3,LIN Qiang2,JIA Jing1,LI Lu-jun1(1.Department of Graduate Management,AFEA,Wuhan 430019,China;2.Department of Land-Based Early Warning Surveillance Equipment,AFEA,Wuhan 430019,China;3.Unit 95980 of PLA,Xiangyang 441021,China);Research on Theoretic System of Radar Site Optimisation Evaluation[J];Electronic Information Warfare Technology;2013-01
8 WANG Xin1,REN Ming-qiu2,GAO Feng3,TAO Hai-yin4 (1.PLA Unit 94981,Nanchang 331200,China;2.Department of Optics and Electronics,OrdnanceEngineering College,Shijiazhuang 050003,China;3.PLA Unit 93046,Shenyang 110141,China; 4.Staff Room of Artillery Nanchang Military Academy,Nanchang 330103,China);Analysis and consideration on combat effectiveness evaluation in radar EW[J];Information Technology;2011-07
9 ZHAN Qing,WANG Ya-dong (Bioinformatics Technology Research Center,Harbin Institute of Technology,Harbin 150001,China);Information entropy analysis of bases distribution in genome translation initiation and termination regions[J];Journal of Natural Science of Heilongjiang University;2011-05
10 SONG Gui-bao,YUAN Hong-wu,LI Hong-liang(Naval Aeronautical and Astronautical University,Yantai 264001,China);Effectiveness Evaluation Method of Terminal Guidance Radar of Anti-ship Missile in Electronic Jamming Conditions[J];Shipboard Electronic Countermeasure;2011-05
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