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《Clinical Education of General Practice》 2009-06
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Expression of killer Ig like receptors 3DL1 on CD8~+ T lymphocytes in patients with idiopathic thrombocytopenic purpura

SHOU Lihong, ZHANG Huiying, PAN Yuefen, et al. Department of Hematology, Huzhou Central Hospital, Huzhou 313000, China  
Objective To analyze the relationship between killer Ig-like receptors 3DL1 (KIR3DL1) and idiopathic thrombocytopenic purpura (ITP). Methods KIR3DL1 expressed on the surface of CD8 + T lymphocytes were determined by flow cytometry in 38 ITP patients and 20 cases blood donors. Results The expression of KIR 3DL1 on CD8+ T lymphocytes in ITP patients before treatment was significantly lower (M=2.30%, Q=1.71%) than that of cured patients (M=3.11%, Q=2.18%)(Z=3.95,P0.05).The expression of KIR 3DL1 on CD8+ T lymphocytes of patients before treatment was significantly lower than that of blood donors too (M =4.03% , Q =2.47% ) (Z =3.45,P 0.05). Conclusions The expression of KIR 3DL1 on CD8+ T lymphocytes decreased in ITP patients, and the destruction of platelets increased. KIR 3DL1 are associated with ITP.
【CateGory Index】: R554.6
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 GONG Wei juan,YANG Jue qin,ZHANG Lei,YAO Fang juan,FAN Li an.Shanghai Second Medical University,Shanghai Institute of Immunology,Shanghai 200025,China;Association of killer cell immunoglobulin-like receptor gene polymorphisms with seronegative spondylarthropathies[J];Chinese Journal of Rheumatology;2003-08
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【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 GONG Wei juan,YANG Jue qin,ZHANG Lei,YAO Fang juan,FAN Li an.Shanghai Second Medical University,Shanghai Institute of Immunology,Shanghai 200025,China;Association of killer cell immunoglobulin-like receptor gene polymorphisms with seronegative spondylarthropathies[J];Chinese Journal of Rheumatology;2003-08
2 ZHANG Lei 1, Katharine C Hsu 2, LIU Xiao rong 2, YANG Jue qin 1, YAO Fang juan 1, XU Ling di 1, Bo Dupont 2, FAN Li an 1(1 Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025,China; 2 Memorial Sloan Kettering Cancer Center, New York, USA);A Study on Human KIR Genotyping by PCR-SSP and Haplotype Defined by the Analysis of Family Segregation[J];Shanghai J.of Immunology;2003-02
3 XU Ling-di, LU Yu, FAN Li-an, YANG Jue qin, YAO Fang-Juan , GU Yue-ying(Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China; Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China);Study on the association between the HLA-B*51 gene with Behcet's disease in Shanghai area[J];;2005-02
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