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《Clinical Education of General Practice》 2017-06
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Effect of oxycodone pretreatment on intrapulmonary shunt and arterial partial pressure of oxygen in patients undergoing thoracic surgery during one-lung ventilation

YU Liang;LIU Yang;Department of Anesthesiology,Huzhou Central Hospital;  
Objective To investigate the effect of pretreatment with oxycodone on intrapulmonary shunt and arterial partial pressure of oxygen in patients undergoing thoracic surgery during one-lung ventilation. Methods Forty patients undergoing elective thoracic surgery were assigned into oxycodone group and control group with 20 cases in each. At 15 minutes before one-lung ventilation,the 0.1 mg/kg of oxycodone mixed with 5 ml normal saline was injected intravenously in oxycodone group,while the control group the equal volume of normal saline. Sevoflurane concentration were adjusted to maintain BIS from 40 to 60. At immediately before one-lung ventilation(T_1),at 10 min(T_2),20 min(T_3)and 30 min(T_4)after one-lung ventilation,the potential of hydrogen(p H),PaO_2,Pa CO_2,MAP of two groups were detected and intrapulmonary shunt(Qs/Qt)were calculated. Results There were no significant differences in p H value,PaCO_2 and BIS at T_1,T_2,T_3,T_4 between the two groups as well as MAP at T_1,T_2,T_4(t=0.78,0.03,0.73,0.49,0.98,0.88,0.71,0.55,0.80,0.47,0.56,0.65,1.34,1.24,0.56,P0.05). Compared with T_1,Qs/Qt was significantly higher,while PaO_2 was significantly lower at T2,T3,T4 in oxycodone group and control group(t=14.69,12.25,16.55,11.82,20.45,16.24; 15.47,20.89,18.34,14.23,17.63,17.70,P0.05). Compared with the control group,Qs/Qt was significantly lower at T2,T3,T4 and PaO_2 was significantly higher at T_2,T_4 in oxycodone group(t=4.52,6.89,4.85,4.63,0.98,P0.05). ETsev in oxycodone group was significantly lower than control group at T_1,T_3,T_4(t=7.08,6.87,5.05,P0.05). Conclusion Intravenous pre-injection 0.1 mg/kg of oxycodone at 15 minutes before one-lung ventilation can reduce the intrapulmonary shunt and increase the arterial partial pressure of oxygen during one-lung ventilation in patients undergoing thoracic surgery.
【Fund】: 2015年浙江省湖州市卫生局科研计划项目(2015GY16)
【CateGory Index】: R614
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