Effect of Paroxetine Associated with Psychological Intervention on Depression in Type 2 Diabetic Patients

SUN Quan-xin,DUAN Wu-gang,CHEN Ke-quan,et al.The Second Hospital Affiliated to Xianning University,Xianning 437100,China  

Objective To explore the clinical curative effect of paroxetine combined with psychological intervention on depressive disorder and blood glucose in type 2 diabetic patients.Methods 64 patients with type 2 diabetes and depressive disorder were randomly assigned to study groupⅠ (routine therapy + paroxetine with psychological intervention,23 cases),study groupⅡ(routine therapy+psychological intervention,21 cases) and control group (routine therapy,20 cases) for 8 weeks′treatment,the clinical effect and side reaction were evaluated separately with HAMD and TESS before and after the treatment.HbA_ 1c levels were obtained to monitor glycemic control.Results After 8 weeks,improvement on HAMD scores was significantly greater in study groupⅠthan that in study groupⅡ or in control group (P0.01),and the scores of HAMD were significantly lower in study groupⅡ than those in control group (P0.05).After the treatment,the improvement on blood levels of HbA_ 1c was significantly greater in study groupⅠthan that in study groupⅡ or in control group (P0.05～0.01),but there was no difference in HbA_ 1c levels between study groupⅡ and control group (P0.05).The severe side effect was not found in three groups during the treatment.Conclusion Paroxetine combined with psychological intervention can efficiently improve the depressive disorder in type 2 diabetic patients,and it is good for controlling blood glucose of the patients.

【Key Words】： Diabetes mellitus type 2 Depressive disorder Paroxetine Psychotherapy
【CateGory Index】： R587.1;R749.2
【DOI】： cnki:ISSN:1007-9572.0.2006-10-012

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