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《Chinese General Practice》 2006-24
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Influence of Compound Shuanghuang Liquor on Intestinal Mucosa Injury and Bacterial Translocation in Rats with Severe Burn

DUAN Jiu-mei,QIU Shu-lin,ZHANG Pei-pei.Department of Burn and Plastic,You′an Men Hospital of Association of Beijing Hospital,Beijing 100069,China  
Objective To discuss the mechanism of compound shuanghuang liquor on protecting the intestinal mucosa injury and inhibiting the bacterial translocation in rats with severe burn.Methods 32 healthy male SD rats were divided into four groups randomly.Rats in normal control group ate food and water freely without scald;rats in scald control group were orally administered 1 ml 0.9% saline an hour before they were scalded and six hours after they were scalded,four times per day;rats in scalded with rhubarb liquor treatment group and scalded with compound shuanghuang liquor treatment group were orally administered equal amount of rhubarb liquor and compound shuanghuang liquor respectively at the same time.72 hours after the scald,the thymus index,spleen index,SlgA lever in intestinal mucus and the frequency of the bacterial translocation were calculated and detected;the changes in histopathology of intestinal mucosa were observed by light microscope and transmission electron microscope.Results Thymus index and spleen index in rats in three scald groups showed significance difference compared with normal control group(P0.05);there were no significant differences in thymus index and spleen index between compound shuanghuang liquor treatment group and scald control group or rhubarb liquor treatment group (P0.05).There was significant difference in the frequency of bacterial translocation in four groups (P0.001),and the frequency of bacterial translocation in compound shuanghuang liquor treatment group differed significantly from that in other three groups (P0.05);Compared with the normal control group,the SlgA level in intestinal mucosa showed significant difference in three scald groups (P0.05).The IgA level in compound shuanghuang liquor treatment group differed significantly from rhubarb liquor treatment group and scald control group (P0.05).The histopathology change of intestinal mucosa in compound shuanghuang liquor treatment group was lightened.Conclusion The compound shuanghuang liquor could effectively prevent the intestinal mucosa injury and inhibit the intestinal bacterial translocation in scalded rats with severe burn.
【Fund】: 河北省医学科学研究重点课题计划(05030)
【CateGory Index】: R285.5
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