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《Chinese General Practice》 2009-20
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Clinical Analysis of 14 Cases with Acute Drug-induced Lung Injury

MENG Ai-hong,WANG Bao-fa,YUAN Ya-dong,et al.Department of Respiratory Medicine,the Second Hospital of Hebei Medical University,Shijiazhuang 050017,China  
Objective To investigate the clinical and radiological features of drug-induced acute lung injury.Methods A retrospective analysis was performed on the clinical and imaging characteristics,treatment and prognosis of 14 acute drug-induced lung injury patients admitted to No 2 or No 3 Hospital affiliated to Hebei Medical University from January 2006 to March 2008.Results Of the 14 patients with acute drug-induced lung injury,2 were caused by vincristine,2 by methopterin,1 by piperacillin/tazobactam,1 by meropenem,1 by norvancomycin,1 by cellcept,1 by azathioprine,1 by cyclophosphamide,1 by chlorambucil,1 by gatifloxacin,1 by cefotaxime sodium,1 by itraconazole.The average onset time was 5 d after medication.Acute lung injury occurred earlier when using antibiotics than when using immunodepressant.Typical clinical manifestations included dyspnea,short breath and hyoxemia.Chest radiographs usually revealed interstitial and alveolar exudation.Conclusion If hypoxia symptoms occur within a short time,breath shortness becomes worsened,Velcro rales may be heard after medication and conditions improved rapidly after using glucocorticoid following drug withdrawal,acute drug-induced lung injury should be taken into account.
【CateGory Index】: R563.8;R595.3
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【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
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