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《Chinese General Practice》 2010-25
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Clinical Study of PEG-IFN alpha-2a with Thymosin α1 in Treatment of Chronic Hepatitis B

ZHANG Guo-shun,SHANG Hua,MA Li-zhuan,et al.Digestion Department of Affiliated Hospital of North China Coal Medical College,Tangshan 063000,China  
Objective To study the clinical efficacy of PEG-IFNα-2a combined with thymosin α1 in treatment of chronic hepatitis B.Methods Totally 83 patients with chronic hepatitis B were randomly divided into two groups (A,B).The patients in the group A (n=42) were treated with PEG-IFN α-2a and thymosin α1;while the patients in the group B (n=41) were treated with PEG-IFNα-2a only.The changes in liver histopathology and the serum levels of HBsAg,HBeAg,HBV DNA were studied before and after the treatment.Results The recovery rates of serum levels of alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were significantly higher in the group A than in the group B after 6-month treatment (P0.05).The negative conversion ratios of HBsAg and HBVDNA were significantly higher in the group A than in the group B after 6-,9-and 12-month treatment (P0.05).The grades of histological hepatocyte inflammation and hepatitic fibrosis were significantly lower in the group A than in the group B after treatment (P0.05).Conclusion PEG-IFNα-2a combined with thymosin α1 is more effective than PEG-IFNα-2a alone for treating patients with chronic hepatitis B.
【Fund】: 唐山市科技攻关指令项目(081302010)
【CateGory Index】: R512.62
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Chinese Journal Full-text Database 1 Hits
1 ZHAO Wen-li,YANG Zhong-min,LIU Hua-ping,GUO Hui (Department of Infection,the Affiliated Jingzhou Hospital of Tongji Medical College,Huazhong University of Science and Technology,Jingzhou 434020,China);Therapeutic Efficacy of Thymosin-α_1 Combined with Lamivudine on Patients with Chronic Hepatitis B[J];Practical Clinical Medicine;2007-02
Chinese Journal Full-text Database 1 Hits
1 HU Hai-bo1,2,XU Ting2,CHENG Kai1,2,SU Na1,2,TANG Yao1,2 1.West China school of Pharmacy,Sichuan University,Chengdu 610041,China 2.Department of Pharmacy,West China Hospital,Sichuan University,Chengdu 610041,China;;Lamivudine Versus Lamivudine-Thymosin alpha-1 Combination Therapy for HBeAg Positive Chronic Hepatitis B:A Systematic Review[J];Chinese Journal of Evidence-Based Medicine;2009-08
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