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《Chinese General Practice》 2012-17
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Plasma Chemerin Levels in Patients with Non-ST Segment Myocardial Infarction/Unstable Angina and Its Influencing Factors

FAN Shu-ying,YU Chang-an,LI Na,et al.China-Japan Friendship Hospital of Ministry of Health,Beijing 100029,China  
Objective To examine the plasma chemerin levels in patients with non-ST segment myocardial infarction/unstable angina(NSTEMI/UA) and its influencing factors.Methods The subjects were divided into three groups according to coronary angiography and the clinical presentation:control group(n=44),stable coronary heart disease group(n=40),and NSTEMI/UA group(n=37).Plasma chemerin level was detemined by ELISA;meanwhile,free blood glucose(FBG),blood lipids,cretinine(Cr),high-sensitivity C-reactive protein(hs-CRP),white blood cell(WBC),plasma fibrinogen and other factors were also analyzed.Results Compared with the control group and stable coronary heart disease group,NSTEMI/UA group has significantly higher plasma chemerin level((229.45±25.47) ng/ml,(203.82±9.89) ng/ml,(214.53±12.24) ng/ml,P0.05).Pearson analysis demonstrated that plasma chemerin level was positively correlated with heart rate(HR),WBC,neutrophil,hs-CRP,fibrinogen,FBG,and Cr(r= 0.605,0.583,0.610,0.608,0.553,0.558 and 0.674,P0.001).Conclusion Plasma chemerin level is significantly elevated in NSTEMI/UA patients and is correlated with HR,SBP,WBC,neutrophil,hs-CRP,fibrinogen,FBG,and Cr.Chemerin may be associated with atherosclerotic vulnerable plaque and play a role in thrombosis.
【CateGory Index】: R541.4;R542.22
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