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《Chinese General Practice》 2012-20
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Correlation of Serum High-sensitivity C-Reactive Protein and Homocysteine Levels with Carotid Artery Atherosclerosis in Acute Cerebral Infarction Patients with Type 2 Diabetes Mellitus

ZHANG Min,LI Wei-zheng.Department of Neurology,Xinxiang Central Hospital,Xinxiang 453000,China  
Objective To explore the correlation of serum high-sensitivity C-reactive protein(Hs-CRP) and homocysteine(Hcy) with carotid stenosis in patients with acute cerebral infarction with type 2 diabetes mellitus(DMCI).Methods Totally 102 acute cerebral infarction patients,including 44 DMCI patients(DMCI group) and 58 patients with non-diabetic acute cerebral infarction(CI group) were enrolled in this study.The serum hs-CRP and Hcy were measured.Carotid artery examination including the inter-media thickness and carotid atheromatous plaque were performed for all patients by the Doppler ultrasonography.Results The serum hs-CRP and homocysteine levels in DMCI group and in CI group showed significant difference(P0.05).The incidence of carotid artery atherosclerosis was 86.4% in DMCI group and 69.0% in CI group(P0.05).Inside the DMCI group,the serum levels of hs-CRP and Hcy also showed significant differences between patients with unstable/stable plaque and those without plaque;in addition,the serum hs-CRP level in patients with unstable plaque also differed from those with stable plaque(P0.05).Conclusion DMCI patients are more susceptible to carotid artery atheroscleros,which may be related with the increased serum hs-CRP and Hcy levels.
【CateGory Index】: R587.1
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