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《Medical Laboratory Science and Clinics》 2008-04
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Experimental study between MMP2,MMP9,TIMP1 and heart failure

Ge Xi,Tao Guohua,Xie Jianpei(The NO.1 hospital of Namtong city,Nantong)  
Objective To investigate the change of MMP2,MMP9,TIMP1's concentration in serum before and after heart failure and after give medicine.Methods Use the rabbit make animal model and then dispart for 3 groups,they are sham operation(SO) group,heart failure comparison(HC) group,heart failure treat with Atorvastatin(HA)group.HC group and HA group establish heart failure model.After 6 weeks of making model,we give HA group Atorvastatin for treatment,and then use ELISA to determine MMP2,MMP9,TIMP1's concentration in serum of 3 groups before the opeartion,after 6 weeks of the opeartion and after 4 weeks of give medicine.Results Before opeartion the levels of several targets of 3 groups have no differences and statistics meanings(P0.05).After 6 weeks of the opeartion,the levels of HC group and HA group all higher than SO group,they have differences and statistics meanings(P0.05).After 4 weeks of give medicine,the level of 3 tragets of HA group is evidencely lower than HC group(P0.05).Conclusions MMP2,MMP9 and TIMP1 attend ventricle remodeling,and it is effective that treat heart failure with Atorvastatin.
【CateGory Index】: R541.6
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