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《Journal of Qilu Oncology》 2004-01
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Inhibiting effect of Fuzheng Anticancer capsule No.1 on the growth of experimental tumor cell lines both in vivo and in vitro

WANG An yu 1,ZHU Xiao dong 1,CHEN Long 1,WANG Shao feng 2,HUANG Ren bin 3 1.Department of Radiotherapy,Cancer Hospital of Guangxi Medical University,Nanning 530021,P.R.China 2.Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,P.R.China 3.College of Pharmacy,Guangxi Medical University,Nanning 530021,P.R.China  
OBJECTIVE:To study the inhibiting effect of Fuzheng Anticancer capsule No.1 (FAC No.1)on the growth of transplant srcoma 180(S180) and HepA ascitic type (HepA) cell lines both in vivo and in vitro .METHODS:Experimental bearing tumor mice were randomly divided into 4 groups.The tests of FAC both in vivo and in vitro were observed respectively.The effect of survival period on transplant HepA ascitic type in mice was also observed.RESULTS: In vivo tests,FAC in a dosage of 30,60 g/(kg·d) inhibited the growth of S180 in mice with an inhibitory rate (IR) of 53 22% and 60 78% respechively and it inhibited the growth of HepA in mice with an IR 36 84% and 45 29%,respectively FAC exerted in vitro inhibitory action on S180 and HepA with an effect of killing cancer directly.FAC also prolonged the survival period of transplant HepA ascitic type mice.CONCLUSIONS:FAC No.1 obviously inhibits proliferation of both cell lines of S180 and HepA both in vivo and in vitro and obviously prolongs the survival period of bearing HepA mice.
【Fund】: 广西壮族自治区科技攻关项目基金资助(桂科攻0 0 15 0 2 3 )
【CateGory Index】: R73-36
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