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《Chinese Journal of Cancer Prevention and Treatment》 2006-11
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Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice

HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China  
OBJECTIVE:To investigate the effect and mechanism of Quercetin and Suramin on hypoxia inducible factor-1α (HIF-1α) and P-Selectin in lung adenocarcinoma LA795 in mice. METHODS: LA795 cells were inoculated into the mice to eslablish lung adenocarcinoma model. Forty T739 mice were randomized into five groups: A, control group, B, DDP group; C, Quercetin group; D, Suramin group; E, Quercetin + Suramin group. Different treatments were served and all mice were sacrificed after 3 weeks. The metastasic tumor foci on lung in mice, tumor weight and tumor growth inhibition rate were observed. Lung metastasis occurring rate and metastasic foci inhibitory rate were counted. Subcutaneous tumor HIF-1α and P-Selectin were determined by the immunohistochemistry method image analyse system. RESULTS: The growth inhibition rates of DDP group, Quercetin group, Suramin group and Quercetin+Suramin group were 23.03%, 39.77%, 34.40% and 54.70% respectively. The metastasic foci on lung surface of control group,DDP group, Quercetin group, Suramin group and Quercetin+Suramin group were 11.00±1.927,8.75±1.642,6.00±1.600,3.00±2.000 and 1.37±1.187, respectively. The greys of HIF-1α were 85.1±3.72, 86.9± 4.31,96.1±4.78,97.9±5.02 and 111.9±5.48 respectively, and the greys of P-Selectin 77.20±4.37,80.20±4.74,96.10±5.23,111.90±5.04 and 127.40±5.96, respectively. In every treatment group, tumor growth was suppressed significantly, and the combination group significantly enhanced anti-tumor efficacy. The metastasic foci on lung surface were obviousy inhibited by Suramin or Quercetin compared with the control group. Contrary to DDP, the expressions of subcutaneous tumor HIF-1α, P-selectin, and lung metastasis occurring rate were also obviously inhibited by Suramin. The combined group showed great synergetic effect in decreassing metastasic foci on lung surface. CONCLUSIONS: Quercetin combination with Suramin can inhibit tumor growth and lung metastasis in vivo of lung adenocarcinoma LA795 in mice. The fact that they inhibite tumor growth and lung metastasis of lung adenocarcinoma LA795 may be associated with the effect by suppressing the expressions of HIF-1α and P-Selection in tumor.
【Fund】: 湖南省卫生厅科研基金资助(C2005033)
【CateGory Index】: R734.2
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