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《Chinese Journal of Cancer Prevention and Treatment》 2007-03
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Expressions and clinical significance of EGFR and EGFRv Ⅲ in mammary tumor

ZHAO Yin-nong1,HE Ni2,OU Chao1,CAO Ji1,CHEN Jun1,LIU Jian-Yong1,YUAN Wei-Ping1 1.Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,P.R.China 2.Department of Surgery,Guangxi Minzu Hospital,Nanning 530001,P.R.China  
OBJECTIVE:To explore the expressions and clinical significance of EGFR and EGFRv Ⅲ in human breast cancer tissues and benign mammary hyperplasia.METHODES: SupervisionTM immunohistochemical staining(IHC) was used to detect the expressions of EGFR and EGFRv Ⅲ in 30 specimens of human benign mammary hyperplasia tissues,55 specimens of human breast cancer tissues,all their adjacent non-cancerous mammary tissues and metastasis lymph nodes.RESULTS: The positive rate of EGFR in breast cancer tissues was significantly higher than that in adjacent non-cancerous mammary tissues and metastasis lymph node tissues(72.7%,29.1% vs 58.3%,χ2=5.326,P=0.021).The positive rate of EGFRv Ⅲ in breast cancer tissues was significantly higher than that in adjacent non-cancerous mammary tissues and metastasis lymph node tissues(52.7%,1.8% vs 45.8%,χ2=4.718,P=0.030).The positive rate of EGFR was significantly correlated with the pathologic grade(χ2=11.840,P=0.002),the number of local metastasis LN(χ2=13.715,P=0.000),ER-(χ2=10.785,P=0.007) and PR-(χ2=4.727,P=0.031).The positive rate of EGFRv Ⅲ was significantly correlated with the pathologic grade(χ2=5.280,P=0.024),distant metastasis(χ2=5.612,P=0.019),the number of local metastasis LN(χ2=4.464,P=0.038),ER-(χ2=3.960,P=0.049),PR-(χ2=17.517,P=0.000) and c-erbB-2 +(χ2=7.524,P=0.005).CONCLUSION: Over-expressed EGFR and EGFRvⅢ may be really related to initiation and progression of breast cancer.EGFRvⅢ could be considered as the marker for predicting the initiation and prognosis of human breast cancer.
【CateGory Index】: R737.9
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