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《Chinese Journal of Cancer Prevention and Treatment》 2007-12
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Expressions and significance of MRP1 mRNA and GST-π mRNA in NSCLC tissues

ZHANG Yong-mei, WANG Zhao-qing, SUN Jian-suo, SONG Guang-yao Key Geriatric Laboratory, Hebei Provincial General Hospital, Shijiazhuang 050051, P.R.China  
OBJECTIVE: To investigate the expressions of multidrug resistance-associated protein (MRP1) and glutathione S-transfase (GST-π) in non-small cell lung cancer (NSCLC) tissues and their relationship with the biological specificity. METHODS: RT-PCR and semiquantitative method of gel electrophoresis-ratio of integral optical density were used to detected the expressions of MRP1 mRNA and GST-πmRNA in 36 samples of NSCLC tissues and in 12 samples of corresponding adjacent tissues. Their different expressions in TNM and the relationship between the two genes in NSCLC tissues were analysed by SAS 8.0 statistic software. RESULTS: The positive ratios of the expressions of MRP1mRNA and GST-πmRNA in NSCLC tissues and corresponding adjacent tissues were 83.3%,88.9%,75.0% and 83.3%. The positive ratios of the expressions of the two genes were not significantly different in the groups of NSCLC and corresponding adjacence. The two genes co-expressed in NSCLC tissues. The expressions of the two genes were significantly increased in NSCLC tissues (IOD ratio=0.740 3,1.267 9) compared with the corresponding adjacent tissues (IOD ratio=0.201 3,0.421 7),each P=0.000. The two genes were not significantly different in the groups of T1-T4,each P0.05. The expressions of the two genes were significantly increased in the groups of lymph node metastasis (ratio IOD=0.849 6,1.387 4) and distance metastasis (ratio IOD=0.958 3,1.579 0) compared with the groups without lymph node metastasis (ratio IOD=0.659 1,1.057 1) and distance metastasis (ratio IOD=0.655 3,1.110 9), P=0.047,0.021,0.042 and 0.015. CONCLUSION: The two genes above mentioned may be a potential basis of predicting prognosis and personalized medicine.
【CateGory Index】: R734.2
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