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《Chinese Journal of Cancer Prevention and Treatment》 2007-15
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Chemoprophylactic effect of celecoxib on N-Methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancer in rat model

JING Da-dao1,LOU Li-hong1,LI En-ling2,LI Ji-kun11.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai JiaotongUniversity,Shanghai 200080,P.R.China2.Shanghai Institute of Digestive Disease,Shanghai 200001,P.R.China  
OBJECTIVE:To investigate the chemoprophylactic effect of celecoxib,a selective cyclooxygenase(COX)-2 inhibitor,on N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)-induced gastric cancer in a rat model.METHODS:One hundred and twenty male Wistar rats were randomized to drink the solution of MNNG and high salt food(Group M),MNNG/celecoxib in early stage(Group MCE),MNNG/celecoxib in later stage(Group MCL),celecoxib(Group C),and water(Group N).The animals were assessed for the presence of gastric cancer,COX-2 expression and precancerous changes in gastric mucosa at the and of 35 weeks.RESULTS:One hundred and eleven(92.5%)rats completed the study.The incidences of gastric carcinoma in Group MCE(4.3%)and Group MCL(22.7%)were significantly lower than that in Group M(71.4%),P0.001.No tumor occurred in Group N and Group C.The incidences of gastric mucosal atrophy,intestinal metaplasia and dysplasia in Group MCE were significantly lower than those in Group M(P0.01 and P0.05,respectively).In Group MCL,however,only the incidences of gastric mucosal dysplasia were significantly lower than in Group M,P0.05.The positive rates of COX-2 protein in Group MCE(26.1%)and in Group MCL(45.5%)were also significantly lower than that in Group M(85.7 %),P0.001 and P0.01.CONCLUSIONS:The selective COX-2 inhibitor celecoxib can significantly inhibit the development of gastric cancer and precancerous changes induced by MNNG in the model of rat.This provides an evidence that COX-2 inhibitors may have chemoprophylactic potential in human gastric cancer.
【Fund】: 上海市卫生局青年基金(局99Y07)
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WAN Mei-zhen,XU Jian-zhong,SHI Yong-juan,CHEN Yu-fang, WANG Mei-hua,PAN Yao-dongDepartment of Pathology,Cancer Hospital of Changzhou,Changzhou 213001,P.R.China;Study on the association of cyclooxygenase-2 expression and dendritic cells infiltration in progressing gastric carcinoma[J];中华肿瘤防治杂志;2006-13
2 WANG Yin ping,SUN Mao feng,WU Xu.Postdoctoral Fellow Research Station,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Correlation between Tight Junction and Experimental Gastric Precancerous Lesion in Rats[J];肿瘤防治杂志;2003-03
3 Zheng Ying, Li Delu, Xu Yaochang. (Department of Chronic Diseases, Shanghai Center for Disease Prevention and Control, Shanghai 200336);The Status and Trend of Stomach Cancer Incidence and Mortality in Shanghai[J];外科理论与实践;2000-03
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 WANG Xinguo;LI Li;GAO Feng;Department of Gastroenterology,People’s Hospital of Xinjiang Uygur Autonomous Region;;Investigation on Relationship between Different Helicobacter pylori Antibodies and Gastric Cancer,Peptic Ulcer and Chronic Gastritis in Xinjiang Area[J];胃肠病学;2016-02
2 Ya-Yun Guo;Mu-Xin Wei;Department of Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University; Institute of Combined Traditional Chinese and Western Medicine of Nanjing Medical University;;Effect of Huatan Xiaoyu Fang on expression of Notch1, β-catenin and PTEN in precancerous lesions of gastric cancer in rats[J];世界华人消化杂志;2015-02
3 WEI Rong;YANG Zhu;LIU Huarong;LI Xin;ZHANG Shuguo;The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine;;Clinical Observation on Yin-Nourishing Masses-Resolving and Phlegm-Transforming Stasis-Removing Therapy Combined with Chemotherapy for 60 Cases of Gastric Cancer[J];中医杂志;2014-21
4 LI Guohua;CHEN Youxiang;GUO Guihai;Department of Gastroenterology,First Affiliated Hospital of Nanchang University;;Clinicopathological characteristics of 613 patients with early gastric cancer[J];江西医药;2014-09
5 ZOU Wen-bin;LI Zhao-shen;;Progress in research China morbidity and mortality of gastric cancer[J];中国实用内科杂志;2014-04
6 Feng-Li Wu;Guo-Hua Li;Department of Gastroenterology,the First Affiliated Hospital of Nanchang University;;Dendritic cell vaccines in gastric cancer immunotherapy[J];世界华人消化杂志;2014-01
7 QIU Yan-zhe;SUN Gang;BI Jian-wei;General Surgery Department;;Clinical application of shuertai irrigation after operation of gastric carcinoma[J];中国实用外科杂志;2013-S1
8 Lu Qiang1,Zang Aimin1,Feng Shuming2(1.Department of Pathology,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China; 2.Department of Internal Medicine,Maternal and Child Health Hospital of Xushui County,Baoding,Hebei 072550,China);Express and significance of PTEN and P27~(kip1) in gastric carcinoma and precancerous lesions[J];重庆医学;2013-05
9 GENG Yi-ting,JIANG Jing-ting,WU Chang-ping.Department of Tumor Biological Treatment,the Third Affiliated Hospital of Soochow University,Changzhou 213003,China;Advances of dendritic cell and immunotherapy in gastric cancer[J];临床肿瘤学杂志;2012-12
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 YIN Xiaoyu, L Mingde, LIANG Lijian, LAI Yingrong, HUANG Jiefu, LI Zhi. Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, 510080, China;Infiltration of dendritic cells and lymphocytes in hepatocellular carcinoma tissue[J];中华外科杂志;2002-05
2 Tang Lijun, Tian Fuzhou, Ma Xiaolin, et al. Centre of Abdominal Surgery, Chengdu Army General Hospital, Chengdu 610083;EXPERIMENTAL STUDY ON THE RELATION BETWEEN THE DAMAGE OF GASTRIC REMNANT MUCOSAL BARRIER AND THE PRECANCEROUS LESION OF GASTRIC REMNANT MUCOSA AFTER SUBTOTAL GASTRECTOMY[J];中国普外基础与临床杂志;1999-01
3 Zhang Zili ,Pu Jikang, Zhao Jianxiong (Lanzhou Medical College,Lanzhou 730000);Ultrastructural study of chronic gastritis treated dialectically with TCM[J];中国中西医结合脾胃杂志;1996-02
4 Li Chunqi; Liu Weiwen; Fang Dianchun;(Department of Gastroenterology, Southwest Hospital, Third Military Medical College, Chongqing, 630038);A study of the establishment of a rat-model of gastric mucosal precancerous lesion and its reverse therapy[J];第三军医大学学报;1994-01
5 SONG Bo-gen LY Yi-qing ZHAO Gui-fen SHI Hong-jun ZHU Qing-yan (Lab. of Cancer Research,, Shanghai Railway Medical College, Shanghai 200070);THE TRAUMATIC DEGREE OF GASTRIC MUCOSA AND PATHOGENESIS OF GASTRIC CANCER[J];癌症;1993-05
6 Li Yi-qing, et al. Lab. Concer Res., Med. Res. Inst, Shanghai Railway Medical College;THE IMPORTANT ROLE OF REPEATED MUCOSAL TRAUMATIC AND ANTI-TRAUMATIC EFFECTS OF THE STOMACH IN PATHOGENESIS OF GASTRIC CANCER IN RATS[J];中华消化杂志;1992-02
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