Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer Prevention and Treatment》 2007-19
Add to Favorite Get Latest Update

Relationship between the expressions of HIF-1α,COX-2 and CD105 in human glioma tissues and clinicopathology

WANG Yan-fen1,DING Yong-ling1,WANG Dong-lin2,SHI Gong-sheng2,ZHOU Xiao-ming1,LI Jia-yu1 1.Department of Pathology,First Hospital of Yangzhou,Yangzhou 225001,P.R.China2.Nantong University,Nantong 226001,P.R.China  
OBJECTIVE:To investigate the relationship between the expressions of HIG-1α,COX-2 and CD105 in human gliomas and clinicopathological features.METHODS:The expressions of HIF-1α,COX-2 and CD105 were eyamined by SP immunohistochemical staining in 70 human glioma specimens and 10 normal human brain tissue specimens,and MVD labeled by CD105 were measured.RESULTS:1)The positive expression rates of HIF-1α,COX-2 and CD105 proteins in gliomas(64.3%,61.4%,74.3%)were significantly higher than those of normal human brain tissues.2)The expressions of HIF-1α,COX-2 and MVD were associated with the pathological grading of gliomas.3)The expression conformation rate of HIF-1α and COX-2 was 70.35%,and there was a positive correlation between the expressions of HIF-1α and COX-2,r=0.583 7,P=0.004.4)The MVD values in HIF-1α and COX-2 positive groups(35.87±4.55);(36.00±4.57)were significantly higher than those in negative groups,respectively(29.19±4.69);(29.48±4.71),and P was both 0.000 0,The MVD value(36.22±4.62)in both HIF-1α positive and COX-2 positive group was significantly higher than those in the other subgroups(33.75±3.59),(28.29±4.33),P=0.000 1,and the expressions of them were all positively correlated with CD105-MVD,r=0.540 5,P=0.005;r=0.465 2,P=0.014.CONCLUSION:The overexpressions of HIF-1α,COX-2 and CD105 may play an important role during the malignant progression of glioma and they were closely associated with tumor angiogenesis,so their cojoined detection may better reveal biological characteristics of glioma.
【CateGory Index】: R739.4
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 ZHAO Huan-fen, ZHANG Yong-mei, HE Chun-nian, SONG Guang-yao, ZHAI Jin-ping Hebei General Hospital, Shijiazhuang 050051, P.R.China;Relation between tumor drug resistance and expression of hypoxia induced factor 1α in lung carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-07
2 WANG Shu-xing,YU Chun-ling,LI Shao-mei,JI Yu-ming,JIANG Hui-feng Yantai Municipal Laiyang Central Hospital,Laiyang 265200,P.R.China;Expression of CD105,VEGF and TGF-β1 in human astrocytoma and their relationship with angiogenesis[J];Chinese Journal of Cancer Prevention and Treatment;2008-22
3 WANG Shu-xing1,YU Chun-ling2,JI Yu-ming1,et al. 1 Department of Neurosurgery; 2 Department of Function; Yantai Municipal Laiyang Central Hospital,Yantai Shandong 265200,China.;Expression of CD105 and TGF-β_1 in human astrocytoma and their significance[J];Journal of Clinical and Experimental Medicine;2009-01
【Citations】
Chinese Journal Full-text Database 3 Hits
1 GUAN Xiao-xiang, CHEN Long-bang Department of Oncology, General Hospital of Nanjing Military Command, Nanjing 210002, P.R.China;Molecular mechanism for COX-2 in carcinogenesis[J];Journal of Qilu Oncology;2004-05
2 DENG Qing, TIAN Fu, SHEN Shu-ying, LI Mi, LI Ming-zhongDepartment of General Surgery, First Hospital of Jingzhou, Jingzhou 434000, P.R.China.;Significance of Cox-2 and FasL protein expressions in colorectal carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2006-01
3 DONG Lun~*, PU Pei-yu, WANG Hu,WANG Guang-xiu,KANG Chun-sheng,JIAO De-rang. *Department of Neurosurgery, Tianjin Medical University General Hospital and Lab of Neurooncology, Tianjin Neurological Institute, Tianjin 300052, China;Study on the expression of epidermal growth factor receptor and p53 in astrocytic gliomas:evidence for a distinct genetic pathway[J];Chinese Journal of Pathology;2006-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Guo-Guang1,2,XIANG Xiao-Juan1,2,HE You-Jian1,2 1.State Key Laboratory of Oncology in South China, Guangzhou,Guangdong,510060, P.R.China 2.Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou,Guangdong,510060, P.R.China;Expression and Clinical Significance of Vascular Endothelial Growth Factor C and D in Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2007-01
2 SONG Chang-Cheng, LU Xiang, CHENG Bin-Bin, DU Juan, LI Bai, LING Chang-Quan Department of Traditional Chinese Medicine, Changhai Hospital, Second Militaty Medical University, Shanghai, 200433, P. R. China;Effects of Melittin on Growth and Angiogenesis of Human Hepatocellular Carcinoma BEL-7402 Cell Xenografts in Nude Mice[J];Chinese Journal of Cancer;2007-12
3 Dong-Xia Yang, Yan-Chun Han, Lu-Ying Liu, Ning Yu, Xia Wang and Yan ShiDepartment of Pathology, Binzhou Medical College, Yantai, Shandong, 264003, P.R. China;Expression and significance of Elf-1 and vascular endothelial growth factor in non-small cell lung cancer[J];Chinese Journal of Cancer;2009-07
4 WANG JIN-XUE,XIANG FENG-GANG(Department of Nephrology,Liaocheng People's Hospital,Liaocheng 252000,China);THE EXPRESSION OF HIF-1α IN HUMAN RENAL DISEASES[J];Acta Academiae Medicinae Qingdao Universitatis;2007-06
5 NIU ZHAO-SHAN,JI XIANG-RUI (Lab of Micromorphology,Qingdao University Medical College,Qingdao 266071,China);RELATIONSHIP AMONG INTRATUMOR MICROVESSEL DENSITY,CLINICOPATHOLOGICAL FEATURES AND CELL PROLIFERATION IN HUMAN ENDOMETRIAL ADENOCARCINOMA[J];Acta Academiae Medicinae Qingdao Universitatis;2008-04
6 ZHANG Hai-ying,LI Yan-ru,WANG Jian-jun,LI Xiao-min,WANG Lin(Key Laboratory of Pathobiology,Ministry of Education,School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Establishment of orthotopic transplantation tumor model of liver cancer and its biological features[J];Journal of Jilin University(Medicine Edition);2009-01
7 SHI Wanyi,LIN Fei,HOU Fengjuan(Department of Oncosurgery,the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China);The Expression of C-erbB-2 and Its Correlation to Tumor Angiogenesis in Primary Breast Carcinoma[J];Journal of Baotou Medical College;2007-05
8 WEI Zi-long HUANG Qiang DONG Jun ZHAI De-zhong ZHU Qing HUO Hong-mei WANG Ai-dong LAN Qing Department of Neurosurgery,Brain Tumor Research Laboratory,Second Affiliated Hospital,Suzhou University,Suzhou 215004,China;EGFR expression analysis in tissue array aiming directly at formation and development of neuroglioma[J];Chinese Journal of Neuromedicine;2007-05
9 ZHANG Shan-Shan, ZHENG Xiang-Rong, YANG Yu-Jia, ZHONG Le, WANG Xia, XIE Min, YU Xiao-He. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China;Adenovirus-mediated VEGF165 gene transfer has neuroprotective effects in neonatal rats following hypoxic-ischemic brain damage[J];Chinese Journal of Contemporary Pediatrics;2008-06
10 YUAN Yang, LIU Xiao-hong, GONG De-jun, LI Bai-ling, HUANG Sheng-dong (Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Recombinant adeno-associated virus mediated RNA interference of angiogenin inhibits growth of human lung squamous cancer cells[J];Academic Journal of Second Military Medical University;2007-04
China Proceedings of conference Full-text Database 1 Hits
1 LIU Yu-bin, LIN Ye, JIAN Zhi-xiang, et al. Depatment of Genaral Surgery, Guangdong Provincial People Hospital, Guangzhou 510080, China;EFFECT OF SOMATOSTATIN ON THE EXPRESSION OF VEGF IN HEPATOCELLULAR CARCINOMA[A];[C];2007
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 ZHANG Yong-mei, WANG Zhao-qing, SUN Jian-suo, SONG Guang-yao Key Geriatric Laboratory, Hebei Provincial General Hospital, Shijiazhuang 050051, P.R.China;Expressions and significance of MRP1 mRNA and GST-π mRNA in NSCLC tissues[J];Chinese Journal of Cancer Prevention and Treatment;2007-12
2 WANG Yong-lai1,LIU Cai-gang2,CHEN Shuang1,HUANG Shuo11.Department of Obstetrics and Genecology,Shengijing Hospital,China Medical University,Shenyang 110004,P.R.China2.Department of Surgical Oncology,First Affiliated Hospital of China Medial University,Shenyang 110001,P.R.China;Effection of HIF-1α and VEGF in tumor angiogenesis of endometrial cancer[J];Chinese Journal of Cancer Prevention and Treatment;2007-15
3 MA Xiao-li1,SUN Hai-ji2,WANG Yun-shan1,HUANG Shu-hong3,XIE Jing-wu3,ZHANG Hong-wei3 1.Central Laboratory,Jinan Central Hospital,Jinan 250000,P.R.China2.College of Life Science,Shandong Normal University,Jinan 250014,P.R.China3.College of Life Science,Shandong University,Jinan 250010,P.R.China;Expressions of Sonic Hedgehog and VEGF in human gastric carcinoma and their clinical significance[J];Chinese Journal of Cancer Prevention and Treatment;2007-24
4 LIN Dan-xia1,LIN Ying-cheng1,KUANG Li-ping2,WU Xian-ying2,WU Ming-yao2,LI De-rui1 1.Department of Medical Oncology,Cancer Hospital,Shantou University Medical College,Shantou 515031,P.R.China 2.Department of Pathology,Shantou University Medical College,Shantou 515031,P.R.China;Expressions and significance of VEGF and Angiopoietin-2 in esophageal squamous cell carcinoma tissue[J];Chinese Journal of Cancer Prevention and Treatment;2008-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved