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《Chinese Journal of Cancer Prevention and Treatment》 2008-07
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Relation between tumor drug resistance and expression of hypoxia induced factor 1α in lung carcinoma

ZHAO Huan-fen, ZHANG Yong-mei, HE Chun-nian, SONG Guang-yao, ZHAI Jin-ping Hebei General Hospital, Shijiazhuang 050051, P.R.China  
OBJECTIVE: To investigate the expression and relation of hypoxia induced factor 1α (HIF-1α) , multidrug resistance related protein(MRP)and GLUTathione S-transferase pi (GST-π) in lung carcinoma. METHODS: The expression of HIF-1α, MRP and GST-π were tested by immunohistochemical method in 42 cases of lung cancer specimens. RESULTES: In 42 cases of lung carcinoma specimens, 35 cases showed positive staining of HIF-1α protein (83.3%); 24 cases showed positive staining of MRP protein (57.1%); and 23 cases of GST-π protein (54.8%). There was significant positive correlation between the expression of HIF-1α and GST-π(χ2=7.69, P=0.005 8), but there was no significant correlation between HIF-1α and MRP( χ2=1.58, P=0.221 9). Compared with the expression of HIF-1α, MRP and GST-π in lung carcinoma tissues of T1 and T2 group, there was markedly increased in the T3 and T4 group (P were 0.020 8, 0.018 8 and 0.009 4 respectively). The expression of HIF-1α, MRP and GST-π with lymphatic metastasis in lung carcinoma was significantly higher than those without lymphatic metastasis (P were 0.014, 0.025 1, and 0.010 3 respectively). CONCLUSIONS: HIF-1α might up-regulate the expression of GST-π. High-level expression of HIF1α, MRP and GST-π is associated with invasion degree and lymphatic metastasis of lung carcinoma.
【CateGory Index】: R734.2
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