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《Chinese Journal of Cancer Prevention and Treatment》 2008-12
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Hypoxia-inducible factor-1,a novel target for cancer cell apoptosis and angiogenesis

LI Yu-mei,CHEN Yong-qiang Department of Orthopedics and Traumatology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,P.R.China  
OBJECTIVE: To review the relationship between hypoxia-inducible factor-1(HIF-1) and apoptosis,angiogenesis of cancer cells.METHODS: Using hypoxia-inducible factor-1,apoptosis and angiogenesis as the ,the full-text data bases such as Chongqingweipu,Elsevier and PubMed central between 2004 and 2007 were searched.One hundred and forty-three related articles were got together.After excluding the articles that have the similar studies,48 articles were analyzed.RESULTS: HIF-1 plays an important role in tumorigenesis and tumor development.Through modulating transcription activity of different target genes,it can promote as well as resist cell apoptosis.Meanwhile,it has biological and clinical values.Its overexpression has relationship with up-regulation of VEGF,angiogenesis and poor prognosis of cancers.CONCLUSION: Owing to the intimate relationship between HIF-1α and apoptosis,angiogenesis of cancer cells,HIF-1 will be a novel target for cancer drug therapy.
【Fund】: 国家自然科学基金(30472223)
【CateGory Index】: R730.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
【Citations】
Chinese Journal Full-text Database 10 Hits
1 HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma[J];Journal of Sichuan University(Medical Science Edition);2007-01
2 FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China);Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws[J];Stomatology;2006-06
3 LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China);HIF-1α expression correlates with angiogenesis in bladder cancer[J];Journal of Clinical Urology;2007-04
4 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
5 LI XiaDepartment of Carcinoma,the Affiliated Hospital of Qinghai College,Xining 810001,P.R.China;Expressions and clinical significance of VEGF and HIF-1α in invasive cervical carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2007-11
6 ZHAO Duan-yi,QIAN Cong-kuan,JIANG Cong-qing,LIU Zhi-shu(The 2nd Department of Surgery,Hubei Provincial Corps Hospital of Chinese People's Armed Police Force,Wuhan 430061,China);Effects of HIF-1α on the apoptosis of colorectal cancinoma[J];Acta Academiae Medicinae CPAPF;2007-06
7 SUN Hong-cheng,QIU Zheng-jun,CAO Jun,LIU Chen,ZHANG Fang,HUANG Ke-jian.Department of General Surgery,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China;HIF-1 alpha expression in pancreatic cancer tissue and its effect on cell apoptosis[J];Chinese Journal of Pancreatology;2007-02
8 JIANG Hong-yuan,FENG You-ji.Department of Obstetrics and Gynecology, Obstetrics and Gynecologic Hospital of Fudan University, Shanghai 200011,China;Inhibition of hypoxia-inducible factor 1α expression and tumor growth in SKOV3 ovarian cancer model by sirolimus[J];Chinese Journal of Obstetrics and Gynecology;2004-07
9 LUO Jun *, PENG Zhi lan, YANG Kai xuan, WANG He, YANG Hong, DONG Dan dan,YAO Xian ying *Department of Obstetrics and Gynecology, Sichuan Provincial People′s Hospital, Chengdu 610072, China;Relation between the expression of hypoxia inducible factor-1α and angiogenesis in ovarian cancer using tissue microarray[J];Chinese Journal of Obstetrics and Gynecology;2005-01
10 ZHANG Jun-wen , WANG Pi-long Department of Gastroenterology, The First Affiliated Hospital, Chongqing University Medical Sciences, Chongqing 400016,China;Expression of HIF-1α and Its Relationship to Apoptosis and Proliferation in Gastric Cancer Cell During Hypoxia[J];Cancer Research on Prevention and Treatment;2006-09
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 DENG Ting,ZHANG Jun-wen(Department of Gastroenterology,The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Relationship of Hypoxia-inducible Factor-1α and Invasion of Gastric Cancer Cells in Hypoxia[J];Chinese Journal of Biologicals;2010-07
2 ZHANG Jun-wen,et al(Department of Gastroenterology,the First Affiliated Hospital,Chongqing Medical University);The effects of hypoxia on invasion and angiogenesis of gastric cancer in vitro[J];Journal of Chongqing Medical University;2010-06
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 AO Hei Sio,LEE Ming Yuen(Institute of Chinese Medical Sciences,University of Macau,Macau,China);Review of the role of Dll4-Notch signaling pathway in angiogenesis[J];Basic & Clinical Medicine;2008-01
2 ZHAO Huan-fen, ZHANG Yong-mei, HE Chun-nian, SONG Guang-yao, ZHAI Jin-ping Hebei General Hospital, Shijiazhuang 050051, P.R.China;Relation between tumor drug resistance and expression of hypoxia induced factor 1α in lung carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-07
3 QIU Ming-zhe,PU Pei-yu(Tianjin Neurological Institute,Tianjin Medical University General Hospital,Tianjin 300052,China);Abnormal Notch Signal Pathway and Carcinogenesis[J];Chinese Journal of Dialysis and Artificial Organs;2008-02
4 WANG Juan (Shanghai Institute of Pharmaceutical Industry, Shanghai 200437);Progress of the Application of Vascular Endothelial Growth Factor and Its Receptor in Anti-tumor Therapy[J];Chinese Journal of Pharmaceuticals;2007-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 FAN Li-fang * ,DIAO Lu-ming,CHEN De-ji,LIU Ming-qiu,ZHU Li-qin,LI Hong-gang,TANG Zhi-jiao,XIA Dong ,LIU Xuan,CH EN Hong-lei Department of Pathology,Medical Co llege,Wuhan University,Wuhan 430071,P.R.China;Expression of HIF-1αand Its Relationship to Apoptosis and Proliferation in Lung Cancer[J];Chinese Journal of Cancer;2002-03
2 WU Huiyan,BIAN Aiping,ZHAO Qian.Department of Obstetrics and Gynecology,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Expression and significance of vascular endothelial growth factor and tumor necrosis factor-α in endometriosis[J];Journal of Practical Diagnosis and Therapy;2006-04
3 MA Shuang-wei,WU Kai-nan,ZHONG Xiao-gang,KONG Ling-quan Department of General Surgery,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,P.R.China;Study of the inhibitory effect of quercetin on transplantation tumor of breast carcinoma cell line MCF-7 in nude mice[J];Journal of Qilu Oncology;2004-03
4 ZHANG Hui-lan, ZHANG Zhen-xiang, XU Yong-jian(Respiratory Department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China);Influence of hypoxia-inducible factor-1 alpha on lung cancer cell A549 growth in vitro and in vivo[J];Chinese Journal of Pathophysiology;2004-08
5 ZHU Ya ping, FENG You jie,CHEN Ya fang, et al (Department of Gynecology Oncology, Shanghai First People's Hospital,Shanghai 200080,China);Hypoxia-induced apoptosis and anti-apoptosis in ovarian cancer cell line SKOV-3ipl cells and its correlation with cell cycle[J];China Oncology;2002-04
6 JIANG Hong-yuan,FENG You-ji. Department of G ynecology, Obstetrics and Gynecologic Hospital of Fudan University, Shanghai 20 0011,China Corresponding author:FENG You-ji;Relationship of hypoxia-inducible factor-1 α expression and vascular endothelial growth factor in SKOV-3 ovarian cancer model[J];Chinese Journal of Obstetrics and Gynecology;2004-11
7 LUO Jun *, PENG Zhi lan, YANG Kai xuan, WANG He, YANG Hong, DONG Dan dan,YAO Xian ying *Department of Obstetrics and Gynecology, Sichuan Provincial People′s Hospital, Chengdu 610072, China;Relation between the expression of hypoxia inducible factor-1α and angiogenesis in ovarian cancer using tissue microarray[J];Chinese Journal of Obstetrics and Gynecology;2005-01
8 JIANG Cong-qing , FAN Li-fang , LIU Zhi-su , QIAN Qun , XIA DongDIAO Lu-ming , HE Yue-ming and AI Zhong-li Department of Colorectal Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China (Jiang CQ, Liu ZS, Qian Q, He YM and Ai ZL) Department of Pathology, Medical College of Wuhan University, Wuhan 430071, China (Fan LF, Xia D and Diao LM);Expression levels and significance of hypoxia inducible factor-1 alpha and vascular endothelial growth factor in human colorectal adenocarcinoma[J];中华医学杂志(英文版);2004-10
9 WU Hounan, LI Yulin, ZHU Guibin, ZHANG Lihong ZHANG Xiuying, HE Xu. Department of Pathology, Basic Medical school, Jilin University, Changchun 130021, China;Expression of vascular endothelial growth factor and its receptor (Flt 1) in breast carcinoma[J];National Medical Journal of China;2002-10
10 Luiza Kanczuga-Koda, Stanislaw Sulkowski, Mariusz Koda, Mariola Sulkowska, Department of Pathology, Medical University of Bialystok, Poland Elzbieta Skrzydlewska, Department of Analytical Chemistry, Medical University of Bialystok, Poland;Connexin 26 correlates with Bcl-xL and Bax proteins expression in colorectal cancer[J];世界胃肠病学杂志(英文版);2005-10
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