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《Chinese Journal of Cancer Prevention and Treatment》 2008-22
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Intervention of strengthening genuine qi on growth and metastasis of osteosarcoma

LI Xiao-wei1,DU Ming-chang2,CAO Xue-wei3 1.Department of Surgery,Guangdong Women and Children Hospital and Health Institute,Guangzhou 510010,P.R.China2.Guangzhou University of Chinese Medicine,Guangzhou 510006,P.R.China3.Department of Orthopaedics,Guangdong Hospital of Traditional Chinese Medicine,Guangzhou 510120,P.R.China  
OBJECTIVE:To investigate the mechanism of effect of strengthening genuine qi on the growth and metastasis of osteosarcoma in a mouse model.METHODS:A mouse osteosarcoma model was established.The membranous milkvetch root injection was used for the intervention on the growth of osteosarcoma by the principle of strengthening genuine qi.The weight of mouse,volume and weight of tumor,tumor inhibitive rate and the expression of VEGF were observed.RESULTS:The mean weight of mouse in the model group and membranous milkvetch root group were(40.81±1.97)g and(43.49±2.64)g,respectively.The tumor volume in the model group and membranous milkvetch root group were(10.11±1.38)cm3 and(8.21±1.16)cm3,respectively.The tumor weight in the model group and membranous milkvetch root group were(6.92±0.88)g and(5.50±0.82)g,respectively.There was a significant difference between the model group and membranous milkvetch root group,P0.05.The tumor inhibitive rate in the membranous milkvetch root group(20.52%)was significantly higher than that in model group.The density change of immunohistochemistry in the model group 〔(9.85±2.07)%〕 was significantly different from that in the membranous milkvetch root group 〔(6.09±1.29)%〕,P0.05.CONCLUSION:Strengthening genuine qi can effectively control the growth of tumor.
【Key Words】: strengthening body resistance osteosarcoma neoplasms matestasis drugs Chinese herbal
【Fund】: 广州中医院大学科研创新基金(2005C040)
【CateGory Index】: R273
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