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《Chinese Journal of Cancer Prevention and Treatment》 2009-01
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Expressions of PPARγ and MMP-7 in esophageal squamous cell carcinoma and their significance

LIU Jiang-hui, LI Jin-mei, ZUO Lian-fu, GUO Jian-wen, LIU Liang, WANG JingDivision of Analytical Cycology, Forth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R.China  
OBJECTIVE:To investigate the expressions and biological significance of PPARγ and MMP-7 in esophageal squamous carcinoma tissnes. METHODS: The expressions of PPARγ and MMP-7 were examined by SP immunohistochemical stain (IHC) in 40 cases of esophageal carcinoma specimens, 25 cases of dysplasia and 13 cases of normal tissues. Moreover, they were examined in 30 cases of esophageal carcinoma specimens, 15 cases of dysplasia and 10 cases of normal tissues by FCM. RESULTS: The positive expression rate of PPARγ in esophageal carcinoma (52.5%,21/40) was significantly higher than that in dysplasia (20.0%,5/25) and normal tissues (7.7%,1/13),P0.05, and high expression of PPARγ was correlated with the tumor differentiation and metastasis of esophageal squamous cell carcinoma,P0.05. The positive expression of MMP-7 in esophageal carcinoma (65.0%,26/40) was significantly higher than that in dysplasia (28.0%,7/25) and normal tissues (0),P0.05, and high expression of MMP-7 was correlated with the invasion and metastasis of esophageal squamous cell carcinoma, P0.05. There was a negative correlation between MMP-7 and PPARγ. CONCLUSION: PPARγ and MMP-7 can be involved in carcinogenesis and progression of esophageal squamous cell carcinoma.
【Fund】: 河北省自然科学基金(301351);; 河北省普通高校强势特色学科(冀教高〔2005〕52号)
【CateGory Index】: R735.1
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