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《Chinese Journal of Cancer Prevention and Treatment》 2009-19
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Expression and correlation with prognosis of p190-B RhoGAP in patients with lung adenocarcinoma

WANG Cheng1,LI Bao-zhong2,WAN Jun-ting2,TAN Xiao-gang2,QIU Bin2,XING Xue-zhong2,SHAO Kang2,HE Jie2,ZHANG You-cheng1 1.Department of Thoracic Surgery,Second Hospital of Lanzhou University,Lanzhou 730030,P.R.China 2.Department of Thoracic Surgery,Cancer Hospital (Institute),Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100021,P.R.China  
OBJECTIVE:To detect the expression of p190-B RhoGAP in lung adenocarcinoma and inverstigate its clinical significance. METHODS:The records of 160 patients undergoing complete resection for lung adenocarcinoma were reviewed to collect datas. The expression levels and associativity with clinicopathologic characteristics of p190-B RhoGAP were analyzed using immunohistochemistry method. Statistical analysis was performed to correlate its expression with clinical characteristics and prognosis. RESULTS:p190-B RhoGAP was shown to be over expressed in 43.75%(70/160) lung adenocarcinoma samples (P=0.003),and mainly located in cytoplasm. The expression of p190-B RhoGAP was significantly correlated with the stage of clinicopathology (P=0.018),histologic differentiation (P=0.047),and prognosis (P=0.015);it is a self-sustainingly prognosis factor. Compared with low expressed ones,the patiens with increased p190-B RhoGAP expression was associated with poor survival of lung adenocarcinoma (5-year survival rate:45.7% vs 23.5%). CONCLUSION:p190-B RhoGAP may be a valuable tumor marker for lung adenocarcinoma.
【CateGory Index】: R734.2
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