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《Chinese Journal of Cancer Prevention and Treatment》 2010-09
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Role of adrenomedullin in pulmonary tumor

HAO Shu-ling,YU Zhong-he General Hospital of Beijing Militany Region,Beijing 100700,P.R.China  
OBJECTIVE:To review the document about the relationship between adrenomedullin and pulmonary tumor.METHODS:PubMed central and CHKD periodical full-text databases were retrieved with the key words of peptide,adrenomedullin,pulmonary and tumor.The 40 pertinent literature from 1993 to 2009 was screened.The inclusion criteria:1)the expression of adrenomedullin in pulmonary tumor.2)the role of adrenomedullin in regulation of tumor cell.3)the effect of adrenomedullin in tumor angiogenesis.4)the advanced research of mech-anism of adrenomedullin.Eventually,21 documents were internalized.RESULTS:Adrenomedullin(ADM)is highly expressed in various tumor tissues and cell types,including lung cancer.It is suggested that ADM may be involved in lung carcinogenesis.NSCLC cells are important targets of AM and AM may regulate activities in these malignant lung cells through differential induction of various early response genes including c-fos,c-jun and egr-1.Hypoxia is one of the characteristic microenvironments of tumor growth.The expression of ADM in lung cell is regulated by HIF-1.Targeting adrenomedullin receptors(AM-Rs)inhibits tumor angiogenesis and suppresses the growth of human tumor in mice.AM-Rs are also synthesized in vivo and in vitro by a variety of tumor cells that also express the ligand.The present findings suggest that the ADM/AM-R regulatory system plays a major role in respiratory physiology and lung carcinogenesis.CONCLUSION:The inhibition of the interaction between peptide hormones and their receptors,utilization of negative growth factors,interruption of the signal transduction pathways,or effecting decreased peptide hormones and(or)receptor expression seem logical possibilities for new and specific treatment approaches,which hopefully will translate into new,less toxic,more effective,and desperately needed lung cancer treatment.
【Fund】: 国家自然科学基金(30973491)
【CateGory Index】: R734.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Huan-fen, ZHANG Yong-mei, HE Chun-nian, SONG Guang-yao, ZHAI Jin-ping Hebei General Hospital, Shijiazhuang 050051, P.R.China;Relation between tumor drug resistance and expression of hypoxia induced factor 1α in lung carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-07
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
2 WANG Cheng1,LI Bao-zhong2,WAN Jun-ting2,TAN Xiao-gang2,QIU Bin2,XING Xue-zhong2,SHAO Kang2,HE Jie2,ZHANG You-cheng1 1.Department of Thoracic Surgery,Second Hospital of Lanzhou University,Lanzhou 730030,P.R.China 2.Department of Thoracic Surgery,Cancer Hospital (Institute),Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100021,P.R.China;Expression and correlation with prognosis of p190-B RhoGAP in patients with lung adenocarcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2009-19
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 ZHANG Yong-mei, WANG Zhao-qing, SUN Jian-suo, SONG Guang-yao Key Geriatric Laboratory, Hebei Provincial General Hospital, Shijiazhuang 050051, P.R.China;Expressions and significance of MRP1 mRNA and GST-π mRNA in NSCLC tissues[J];Chinese Journal of Cancer Prevention and Treatment;2007-12
2 WANG Yong-lai1,LIU Cai-gang2,CHEN Shuang1,HUANG Shuo11.Department of Obstetrics and Genecology,Shengijing Hospital,China Medical University,Shenyang 110004,P.R.China2.Department of Surgical Oncology,First Affiliated Hospital of China Medial University,Shenyang 110001,P.R.China;Effection of HIF-1α and VEGF in tumor angiogenesis of endometrial cancer[J];Chinese Journal of Cancer Prevention and Treatment;2007-15
3 WANG Yan-fen1,DING Yong-ling1,WANG Dong-lin2,SHI Gong-sheng2,ZHOU Xiao-ming1,LI Jia-yu1 1.Department of Pathology,First Hospital of Yangzhou,Yangzhou 225001,P.R.China2.Nantong University,Nantong 226001,P.R.China;Relationship between the expressions of HIF-1α,COX-2 and CD105 in human glioma tissues and clinicopathology[J];Chinese Journal of Cancer Prevention and Treatment;2007-19
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