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《Chinese Journal of Cancer Prevention and Treatment》 2010-22
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Meta-analysis of case-control trials on risk factors of ovarian neoplasm

FENG Dan,LIU Jia-li,XU Chong-an Department of Oncology,Fourth Affiliated Hospital,China Medical University,Shenyang 110032,P.R.China  
OBJECTIVE:To investigate potential risk factors of ovarian neoplasm and their pathogenic mechanism.METHODS:Search the CBMDISC,CNKI,VIP and Wanfang database by computer retrieval.Relevant journals,conference papers,thesis and reference list for clinical controlled trials on risk factors of ovarian cancer were also searched by manual retrieval.Two reviewers independently assessed trial quality and extracted data.The Cochrane Collaboration's software RevMan 5.0 was used for meta-analysis.RESULTS:Nine studies involving 3 169 patients were identified,including 1 320 cases in case group and 1 849 cases in control group.The results of meta-analysis showed that:menarche age,first delivery age,dysmenorrhea history,infertility history,family history of cancer,bowel irregularity history and negative life events were the risk factors of ovarian cancer.However,full-term pregnancy,multiple pregnancy history,prolific history,lactation history,repeated abortions history,multiple marriages history,contraceptive taking history and intrauterine history were the protective factors of ovarian cancer.CONCLUSIONS:The main risk factors of ovarian cancer include menarche age,first delivery age,dysmenorrhea history,infertility history,family history of cancer,bowel irregularity history and negative life events.However,full-term pregnancy,multiple pregnancy history,prolific history,lactation history,repeated abortions history,multiple marriages history,contraceptive taking history and intrauterine history are the protective factors of ovarian cancer.
【CateGory Index】: R737.31
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