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《Chinese Journal of Cancer Prevention and Treatment》 2012-12
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Recent genomic research and development of hepatocarcinoma multidrug resistance

LI Pei-kun,GENG Xiao-ping Department of Surgury,Second Affiliated Hospital of Anhui Medical University,Hefei 230601,P.R.China  
OBJECTIVE:To summary the recent researches of hepatocarcinoma multidrug resistance-related genes.METHODS:Literature about hepatocarcinoma multidrug resistance-related Genes were searched for with hepatocarcinoma,multidrug resistance and gene as key words in Medline and CNKl date-base mainly from 2000 to 2011.And 129 literatures were got Inclusion criteria:resistance genes;multidrug resitance;mechanism of resistance.According to the criteria,31 papers were analyzed.RESULTS:MDR,MRP,LRP,BCRP,GST,TOPO,Bcl-2,Survivin,p53,HIF-1,ErbB-2/neu,Rb,c-myc,Clusterin,PYK-2 genes and relevant expressed products play a role in the formation of hepatocarcinoma multidrug resistance,mainly through accelerating drug transfer to the extracellular,promoting drug metabolism,promoting cell proliferation,inhibiting apoptosis,inducing hypoxia,upregulating oncogene and involving in cell signal transduction.The mechanism of MDR,MRP,LRP,BCRP has been more clear,others associated with the resistance of multidrug resistance of hepatocarcinoma significantly.CONCLUSION:Screening and in-depth studyding of hepatocarcinoma multidrug resistance-related genes,exploring the mechanism from gene level,are expected to provide new ways of reversing hepatocarcinoma multidrug resistance.
【Fund】: 2008年安徽省科技攻关面上项目(08010302191)
【CateGory Index】: R735.7
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