Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Cancer Prevention and Treatment》 2013-15
Add to Favorite Get Latest Update

Influence of HIF-1α in cell proliferation and angiogenesis of breast cancer

FENG Rui-fa1,BAI Lu1,LIU Xiao-meng1,GONG Xiao-jie2 1.Department of Breast Surgery,Affiliated Hospital of Guilin Medical College,Guilin 541001,P.R.China 2.Department of Histoembryology,Guilin Medical College,Guilin 541004,P.R.China  
OBJECTIVE:To examine the expression of hypoxia inducible factor-1α(hypoxia-inducible factor 1α,HIF-1α),tumor cell proliferation antigen Ki-67 and vascular endothelial growth factor(vascular endothelial growth factor,VEGF) in tissue of breast,and investigate the influence of HIF-1αimpact on both tumor cell proliferation and angiogenesis in breast cancer tissues.METHODS:Using Immunohistochemistry HRP method to detect expression of HIF-1α,Ki-67 and VEGF in 70 cases of breast cancer and their adjacent tissues as well as 10 cases of normal breast tissue.RESULTS:The expression rates of HIF-1α were 78.6%(55/70) in breast cancer tissues,and 45.7%(32/70) in adjacent tissues.The positive expression rates of Ki-67 for the two tissues were 88.6%(62/70) and 11.4%(8/70).In addition,the positive expression rates of VEGF for the two tissues were 65.7%(46/70) and 34.3%(24/70).These three factors showed no expression in normal breast tissues.These survey results indicated that expression of the three indicators in breast cancer were significantly higher than that in adjacent tissues and normal tissues(P0.01),and they were closely related with clinical stage and lymph node metastasis(P0.05).The expression intensity of HIF-1α was positively correlated with Ki-67 and VEGF in breast cancer(r values were 0.65 and 0.48,and all P0.01).CONCLUSIONS:The expression of HIF-1α,Ki-67 and VEGF are high in breast cancer,which are associated with the malignancy degree of tissue.They may be important indicators of predicting the invasion,metastasis and prognosis in breast cancer.It suggests that HIF-1α may affect the tumor cell proliferation and angiogenesis through some interaction in breast cancer.It is expected to become a new target for treatment of breast cancer and it is worthy for further study.
【Fund】: 广西卫生厅课题(Z2008263)
【CateGory Index】: R737.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 GAO Wei1,LI Lian-hong2(1.Department of General Surgery,Dalian Central Hospital,Dalian 116033,China;2.Department of Pathology & Forensic Medicine,Dalian Medical University,Dalian 116044,China);Expressions of IGF-2 and Ki-67 in breast cancer[J];Journal of Dalian Medical University;2010-01
2 TANG Bin1,ZHOU XiuMei1 & QIAN QiJun1,2 1 Xinyuan Institute of Medicine and Biotechnology,School of Life Sciences,Zhejiang Sci-Tech University,Hangzhou 310018,China;2 Laboratory of Gene and Viral Therapy,Eastern Hepatobiliary Surgery Hospital,The Second Military and Medical University,Shanghai 200433,China;Regulation of HIF-1 activity in tumor cells[J];Chinese Science Bulletin;2009-20
3 CHEN Jun,CHEN Fa-long Department of Pathology,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,P.R.China;Expressions of Survivin and HIF-1α in breast cancer and their clinical significance[J];Chinese Journal of Cancer Prevention and Treatment;2008-10
4 LI Yu-mei,CHEN Yong-qiang Department of Orthopedics and Traumatology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,P.R.China;Hypoxia-inducible factor-1,a novel target for cancer cell apoptosis and angiogenesis[J];Chinese Journal of Cancer Prevention and Treatment;2008-12
5 JIA Shi,ZHANG Wen-hai,LI Jian-yi,ZHANG Yang(Department of Breast Surgery,Shenjing Hospital,China Medical University,Shenyang 110004,China);Expressions of Ki-67 and p53 and Their Significance in Breast Cancer[J];Journal of China Medical University;2010-12
Chinese Journal Full-text Database 10 Hits
1 CHENG Wei 1,ZHOU Weiguo 2(1 Department of Otolaryngology,Nanhai Hospital of Southern Medical University,Foshan,Guangdong 528200,China;2 Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Beijing,100730,China);Clinical significance and the relationship between vascular growth correlation factor and microvessel density, lymph vessel density expression in laryngeal carcinoma[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2012-03
2 HU Jiacai,LI Qingquan(Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China);Effect of Tetramethypyrazine on the Expression of HIF-1α in the Lung Adenocarcinoma A549 Cell Line at Hypoxia[J];Journal of Hubei University of Chinese Medicine;2011-04
3 SHI Chuanwen,LIU Fuli,LIANG Xiaodong,et al.Taishan Sanitarium of Shandong Province,Taian,271000,China.;Research of Basil capsule on expression of HIF-1α,VEGF in hypoxia environmental and sICAM-1 in blood serum after TACE of rat hepatoma[J];Chinese Imaging Journal of Integrated Traditional and Western Medicine;2010-02
4 YANG Da-jiang, LIANG Xin-hua. (Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041,China);Role of Nitric Oxide in Tumor Lymphangiogenesis[J];Journal of Oral and Maxillofacial Surgery;2007-02
5 LIAO Zhi-dong1,ZHENG Shao-qiu1,KUANG Ya-ling2,ZHU Wen-biao1,XIE Shou-cheng1,WU Guo-wu3(1Department of Pathology,3Department of Chemotherapy,Zhongshan University Affiliated Meizhou City People's Hospital,Meizhou 514031,China;2Department of Pathology,Cancer Cencer,SUN Yat-sen University,Guangzhou 510060,China);The role of HER-2,HIF-1a,GLUT-1 and VEGF in lymph node metastasis of breast invasive ductal carcinoma[J];Chinese Journal of Clinical and Experimental Pathology;2012-01
6 LI Lei-yu 1,ZHANG Jun-hua1,ZHANG Yin-xu1,LI Wei2(1.Department of General Surgery,the First Affiliated Hospital of Liaoning Medical College,Jinzhou 121000,China;2.Traditional Chinese Medicine Division,the First Affiliated Hospital of Liaoning Medical College,Jinzhou 121000,China);Experimental study on tetramethylpyrazine in anti-angiogenesis of colorectal cancer sw620 xenografts in nude mice and its tumor-inhibitory mechanism[J];Journal of Southeast University(Medical Science Edition);2010-05
7 LI Hong,et al.Ningxia Medical University,Yinchuan 750004,China;Expression of TopoⅡ,P170,GST-π,PCNA and E-Cadherin in breast cancer and their correlations with clinical prognosis[J];Ningxia Medical Journal;2013-01
8 Liu Denghui, Liu Hongguang (Department of Oncosurgery, First Affiliated Hospital of University of South China, Hengyang, Hunan, 421001, China);Advances of Effects of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor in Breast Cancer[J];Anti-tumor Pharmacy;2013-01
9 Xiaojian Ni;Yingchun Zhao;Jingjing Ma;Tiansong Xia;Xiaoan Liu;Qiang Ding;Xiaoming Zha;Shui Wang;Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University;Department of Breast Surgery, The Second People's Hospital Affiliated with Wannan Medical College;State Key Laboratory of Reproductive Medicine, Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University;;Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients[J];生物医学研究杂志(英文版);2013-06
10 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Wen-Zhou, YU Li-Bo, ZHANG Qing-Yuan Affiliated Tumor Hospital, Harbin Medical University, Harbin 150040, China;Expression and role of HIF-1α in carcinogenesis and progression of breast cancer[J];Journal of the Fourth Military Medical University;2007-02
2 HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma[J];Journal of Sichuan University(Medical Science Edition);2007-01
3 FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China);Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws[J];Stomatology;2006-06
4 LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China);HIF-1α expression correlates with angiogenesis in bladder cancer[J];Journal of Clinical Urology;2007-04
5 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
6 LI XiaDepartment of Carcinoma,the Affiliated Hospital of Qinghai College,Xining 810001,P.R.China;Expressions and clinical significance of VEGF and HIF-1α in invasive cervical carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2007-11
7 GUAN Hai-tao,XUE Feng-jie,WANG Xi-jing,XUE Xing-huan,LIU Xiao-xu,DAI Zhi-Jun,MIN Wei-li,SONG Ling-qin Department of Oncosurgery,the Second Affiliated Hospital of Xi'an Jiaotong University Medical College,Xi' an,Shaanxi 710004,China;Prognostic value of survivin expression in breast cancer[J];Journal of Modern Oncology;2007-07
8 ZHAO Duan-yi,QIAN Cong-kuan,JIANG Cong-qing,LIU Zhi-shu(The 2nd Department of Surgery,Hubei Provincial Corps Hospital of Chinese People's Armed Police Force,Wuhan 430061,China);Effects of HIF-1α on the apoptosis of colorectal cancinoma[J];Acta Academiae Medicinae CPAPF;2007-06
9 JIANG Hong-yuan,FENG You-ji.Department of Obstetrics and Gynecology, Obstetrics and Gynecologic Hospital of Fudan University, Shanghai 200011,China;Inhibition of hypoxia-inducible factor 1α expression and tumor growth in SKOV3 ovarian cancer model by sirolimus[J];Chinese Journal of Obstetrics and Gynecology;2004-07
10 LUO Jun *, PENG Zhi lan, YANG Kai xuan, WANG He, YANG Hong, DONG Dan dan,YAO Xian ying *Department of Obstetrics and Gynecology, Sichuan Provincial People′s Hospital, Chengdu 610072, China;Relation between the expression of hypoxia inducible factor-1α and angiogenesis in ovarian cancer using tissue microarray[J];Chinese Journal of Obstetrics and Gynecology;2005-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved