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《Chinese Journal of Cancer Prevention and Treatment》 2013-15
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Influence of HIF-1α in cell proliferation and angiogenesis of breast cancer

FENG Rui-fa1,BAI Lu1,LIU Xiao-meng1,GONG Xiao-jie2 1.Department of Breast Surgery,Affiliated Hospital of Guilin Medical College,Guilin 541001,P.R.China 2.Department of Histoembryology,Guilin Medical College,Guilin 541004,P.R.China  
OBJECTIVE:To examine the expression of hypoxia inducible factor-1α(hypoxia-inducible factor 1α,HIF-1α),tumor cell proliferation antigen Ki-67 and vascular endothelial growth factor(vascular endothelial growth factor,VEGF) in tissue of breast,and investigate the influence of HIF-1αimpact on both tumor cell proliferation and angiogenesis in breast cancer tissues.METHODS:Using Immunohistochemistry HRP method to detect expression of HIF-1α,Ki-67 and VEGF in 70 cases of breast cancer and their adjacent tissues as well as 10 cases of normal breast tissue.RESULTS:The expression rates of HIF-1α were 78.6%(55/70) in breast cancer tissues,and 45.7%(32/70) in adjacent tissues.The positive expression rates of Ki-67 for the two tissues were 88.6%(62/70) and 11.4%(8/70).In addition,the positive expression rates of VEGF for the two tissues were 65.7%(46/70) and 34.3%(24/70).These three factors showed no expression in normal breast tissues.These survey results indicated that expression of the three indicators in breast cancer were significantly higher than that in adjacent tissues and normal tissues(P0.01),and they were closely related with clinical stage and lymph node metastasis(P0.05).The expression intensity of HIF-1α was positively correlated with Ki-67 and VEGF in breast cancer(r values were 0.65 and 0.48,and all P0.01).CONCLUSIONS:The expression of HIF-1α,Ki-67 and VEGF are high in breast cancer,which are associated with the malignancy degree of tissue.They may be important indicators of predicting the invasion,metastasis and prognosis in breast cancer.It suggests that HIF-1α may affect the tumor cell proliferation and angiogenesis through some interaction in breast cancer.It is expected to become a new target for treatment of breast cancer and it is worthy for further study.
【Fund】: 广西卫生厅课题(Z2008263)
【CateGory Index】: R737.9
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