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《Journal of Qiqihar Medical》 2001-05
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Study on Immunohistochemistry of Islet Cells Injury by Cobalt Nitrate in Rats

Bai Qingyang,et al. (Department of Pathology, Qiqihar Medical College,Qiqihar 161042)  
Objective To observe the selective injury changes of Cobalt nitrate to islet A cells. Methods 42 rats were randomized into seven groups. In 6 rats of the control group, were injected with the solution of sodium chloride 36 rats of the experiment group were musclarly injected (5ml/kg) with the salts solution of cobalt nitrate. To draw the end of the pancreas 1,2,3,4,6,10 days after administration and to finish paraffin section for immunohistochemistry and stereology analysis. Results Islet A cells appear morphological injury after 2 days(P0.05), become more significant after 3, 4 days(P0.001), start to regenerate after 6 days and recover after 10 days. Injury wasn't seen in islet B cells. D cells and PP cells. Conclusion Islet A cells in rats were selective injured by cobalt nitrate and the pathological changes had a good stability and high selection rate.
【Fund】: 黑龙江省自然科学基金资助项目
【CateGory Index】: R392.3
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