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《China Tropical Medicine》 2005-01
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The protective role of Methylene blue by reperfusion in the damage to the lung of rabbit.

CHEN Jie-xiao, WU Xin-min, LIU Yu-he, et al. (Department of Anesthesia of Hainan Provincial People's Hospital, Haikou 570311, Hainan, P.R. China)  
Objective To investigate the effect of pulmonary injury after intestinal ischemia reperfusion(I-R), and the mechanism of methylene blue(MB)to radical oxygen species(ROS) . Methods Thirty two healthy rabbits were randomly divided into four groups. After opening abdomen the fore mesenteric artery was divided carefully.The model of intestinal I-R was developed by occluding the mesenteric artery.Last three groups were occluded the fore mesenteric artery for 60 min.and reperfused for 120 min.The lower MB group was 5mg/kg iv.and the higher MB group was 15mg/kg iv.The level of MDA and the activities of SOD,XOD,CAT and O2 in lung tissue were determined at the end of the experiment. Results The level of O2 - and MDA in the lung tissue were markedly increased than the control group(P 0.05) ,and the level of this two components were not significantly changed in the lower and higher dose groups ( P 0.05 ) . The activities of SOD, XOD in lung tissue were not significantly changed in all groups. The mean artary pressure (MAP) was lower in the I-R group after intestinal I-R( P 0.05) ,but MAP was not changed in two MB group ( P 0.05) . Conclusions MB can reduce lung injury after intestinal I-R. The mechanisms might be associated with the inhibition of the generation of ROS.
【Fund】: 海南省卫生厅重点科研项目资助(琼卫2002-55)
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Lixin,WANG Dixun,HAN Dewu. 1The First Hospital,Shanxi Medical University,Taiyuan Shanxi 030001;Induction of apoptosis and expression of heat shock protein 70 and Bcl-2 genes in human vascular endothelial cells[J];Chinese Critical Care Medicine;2001-02
2 LIU Yu he 1,WU Xinmin 1,CHEN Jiexiao 2,ZHU Jianghua 1,SHAN Guojin 1 1.Laboratory of Anesthesiology,Peking University,The First Hospital,Beijing 100034,China;2.Department of Anesthesiology,Hanian People's Hospital,Haikou 570000,Hainan,China;Protective effects of methylene blue on heart and lung injury after intestinal ischemia-reperfusion[J];Chinese Critical Care Medicine;2002-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 GE Jun,ZHU Yu-jie,WU Jun,YAO Bei-bei (Faculty of Clinical Medicine,Bengbu Medical College,Bengbu 233030,China);Protective effects of gypenosides on the heart injury after intestinal ischemia-reperfusion in rabbits[J];Journal of Bengbu Medical College;2006-04
2 YAN Guang-tao, XUE Hui, LIN Ji, et al.(Research Laboratory of Biochemistry, Basic Medical Institute, General Hospital of PLA, Beijing 100853, China);The Changes and Significance of Serum Leptin Levels in Patients Post-liver Transplantation[J];Labeled Immunoassays and Clinical Medicine;2006-02
3 LUO Gang-jian,GAN Xiao-liang,SHEN Ning,HEI Zi-qing,LI Shang-rong,CHEN Li-xin Department of Anesthesiology,Third Affiliated Hospital,SUN Yat-sen University,Guangzhou 510630,China;Cromolyn sodium ameliorates rat left cardiac function during intestinal ischemia-reperfusion[J];Journal of Southern Medical University;2007-05
4 WU Duo-zhi,LIANG Min,CHEN Jie-xiao,et al. People's Hospital of Hainan Province,Haikou 570311,Haina,P.R.CHINA;Methylene blue prevents lung injury after intestinal ischemia reperfusion in rabbit[J];Hainan Medical Journal;2009-06
5 SHEN Bin LIU Liang FU Ru-lian ZHAO Cheng-mei;Discussion on Photodynamic Action of Methylene Blue (MB)[J];Continuing Medical Education;2005-12
6 ;Observation on Myocardial Injury Caused by Acute Chlordimeform Intoxication[J];Modern Diagnosis & Treatment;2007-04
7 HUANG Hui-fang,MA Fei~* (School of Life Sciences,Xiaman University,Xiamen 361005,China); The Molecular Evolution of Heat Shock Protein[J];Journal of Xiamen University(Natural Science);2004-S1
8 MA Xiao-juan, WANG Hong-mei, ZHANG Jian-long, et al(Department of Pathophysiology, Xinjiang Medical University, Urumqi 830054, China);The alteration of serum endotoxin and the influence on cardiac function during liver ischemia reperfusion injury in rats[J];Journal of Xinjiang Medical University;2007-05
9 MA Qi,MA Xiao-juan,HU Zhi-liang,et al (Department of Pathophysiology,Xinjiang Medical University,Urumqi 830011,China);The protective effect of 654-2 and Nimodipine to the dysfunction of heart during liver ischemia-reperfusion injury[J];Journal of Xinjiang Medical University;2008-07
10 LIU Yu-he , WU Xin-min, CHEN Jie-xiao , et al. Laboratory of Anesthesiology, First Hospital, Peking University, Beijing 100034, China;Methylene blue protects liver from injury induced by reactive oxygen species produced during intestinal ischemia/reperfusion[J];Chinese Journal of Anesthesiology;2003-02
China Proceedings of conference Full-text Database 1 Hits
1 ZHAO Kang-Tao HAI Chun-Xu (Fujian center of disease control and prevention 350001Fuzhou China,2 Fourth Military Medical University 710032 Xian China);Study about expression of family Bcl-2 and oxidated hurt to flepG2 cell induced by micro-dose H_2O_2[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Hu keming (Shengsi Peop1e's Hospital, Shengsi 202450);Clinical Analysis of 100 Patients with Disease due to Wind-Warm and Lung-Heat[J];Journal of Zhejiang College of Tcm;1995-03
2 (Guangdong Hospital of traditional Chinese medicine,Guangzhou,Guangdong 510120,China) HAN Yun,LIN Yan-zhao;TCM Clyster Combined with Non-invasive Ventilation in Treating for Respiratory Failure in Acute Exacerbations of COPD[J];Journal of Fujian College of Traditional Chinese Medicine;2006-02
3 Zhang Shilin, Yu Keli,Bi ping (Biology department,Tianjin Normal university)(Tianjin Friditional Chinese Medicinal Reserch Institute);The Change of NOS Activity in Lung Tissue and no Secreted by Alveolar Phagocyte after the Inchemia reperfusions in Rat′s small Intestine[J];STRAIT PHARMACEUTICAL JOURNAL;2000-02
4 Zhang YunsongPostgraduate 1994,Shandong University of TCM 250014Tutor Zhang Hongcai;Study on Fever in Qifen Phase Treated with Removing Toxic Materials and Purging Bowel[J];JOURNAL OF SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-02
5 YAN Xing ke, ZHANG Guang quan, WANG Yu, YANG Yong qing Shanghai Institute of Acupuncture, Moxibustion and Meridians;New Explanation on Interior and Exterior Relationship between the Lung and Large Intestine[J];Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai;2003-01
6 ZHENG Shun hua CUI Ru tao(10);Experimental Study on Ulcerative Colitis Treated by “Lung-intestine Nourishing Decoction”[J];SHANGHAI JOURNAL OF TRADITIONAL CHINESE MEDICINE;2000-06
7 GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ];Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin[J];Progress In Physiological Sciences;2001-02
8 HE Zhong qian 1, JIANG Jian 2, LU Yi min 2(1.Emergency Dept.,Railway Hospital,Tongji University,Shanghai 200072,China; 2.Emergency Dept.,Affiliated Rui Jin Hospital,Shanghai Second Medical University,Shanghai 200025,China);The Effects of Oxygen Free Radicals on Lung Injury from Intestinal Ischemia-Reperfusion in Rats[J];Journal of Tongji University (Medical Science);2002-05
9 TAO Feng, CONG Pei rong,DING Xiu wen (Pediatrics Department,The General Hospital of Tianjin Medical University 300052);The curative effect and observation on the baihu cheng qi tang oral liqid in treating infantile acute pneumonia[J];JOURNAL OF TIANJIN MEDICAL UNIVERSITY;2000-02
10 YU Ke li,BI Ping,LI Hui qiang,CUI Hua lei (Biology Department , Tianjin Normal University 300074);Effect of the ischemia-reperfusions of small intestine on nitric oxide and nitric oxide synthase in lung tissue of rats[J];JOURNAL OF TIANJIN MEDICAL UNIVERSITY;2000-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Jianchang,WANG Lenong,SHI Zhenman,et al.Department of Orthopaedics,Ulumqi General Hospital of Lanzhou Command,Ulumqi 830000;Protective effect of mannitol on lung injury after lower limb ischemicreperfusion[J];CHINESE CRITICAL CARE MEDICINE;2000-06
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