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《China Tropical Medicine》 2005-01
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The protective role of Methylene blue by reperfusion in the damage to the lung of rabbit.

CHEN Jie-xiao, WU Xin-min, LIU Yu-he, et al. (Department of Anesthesia of Hainan Provincial People's Hospital, Haikou 570311, Hainan, P.R. China)  
Objective To investigate the effect of pulmonary injury after intestinal ischemia reperfusion(I-R), and the mechanism of methylene blue(MB)to radical oxygen species(ROS) . Methods Thirty two healthy rabbits were randomly divided into four groups. After opening abdomen the fore mesenteric artery was divided carefully.The model of intestinal I-R was developed by occluding the mesenteric artery.Last three groups were occluded the fore mesenteric artery for 60 min.and reperfused for 120 min.The lower MB group was 5mg/kg iv.and the higher MB group was 15mg/kg iv.The level of MDA and the activities of SOD,XOD,CAT and O2 in lung tissue were determined at the end of the experiment. Results The level of O2 - and MDA in the lung tissue were markedly increased than the control group(P 0.05) ,and the level of this two components were not significantly changed in the lower and higher dose groups ( P 0.05 ) . The activities of SOD, XOD in lung tissue were not significantly changed in all groups. The mean artary pressure (MAP) was lower in the I-R group after intestinal I-R( P 0.05) ,but MAP was not changed in two MB group ( P 0.05) . Conclusions MB can reduce lung injury after intestinal I-R. The mechanisms might be associated with the inhibition of the generation of ROS.
【Fund】: 海南省卫生厅重点科研项目资助(琼卫2002-55)
【CateGory Index】: R96
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