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《China Tropical Medicine》 2009-02
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Effect of isosorbide mononitrate on experimental gastric ulcer in rats

LUO Yi-bin,LIAO Nü-zhu,CHEN Jian-hui,et al.(1.The Affiliated Hospital of Guangdong Medical College,Zhanjiang,524023,Guangdong,P.R.China)  
Objective To investigate the effect of isosorbide mononitrate on experimental gastric ulcer in rats.Methods The rat model of gastric ulcer was induced by acetic acid.Fifty SD rats were randomly divided into normal control group,gastric ulcer placebo group,lansoprazole treated control(5mg/kg),high isosorbide mononitrate dose group(4mg/kg) and low isosorbide mononitrate dose group(2mg/kg).Forthteen days after treatment,the gastric ulcer tissues were collected for examination of the size and surface area of the ulcer,and stained with HE,AB -PAS.pH of gastric juice were determined.Results Index of gastric ulcer was decreased and HE indicated that gastric mucous membrane were repaired in all treatment group compared with gastric ulcer placebo group.PAS positive in low dose Isosorbide mononitrate treatment group was lower than that in gastric ulcer placebo group,but it was identical to that of normal control group.Conclusion Isosorbide mononitrate can promote the healing of gastric ulcer in rats.
【Fund】: 广东省科技计划项目(编号:2004B30101003)
【CateGory Index】: R573.1
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