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Clinical and pathogenic features of septisis in senile diatectic patients

LI Wen-li,WU Shi-pin,CHEN Hong-tao,et al(Department of Infectious Diseases,the Second Clinical Medical College,Jinan University,Shenzhen 518020,Guangdong, P. R.China)  
Objective To survey the clinical characteristic and pathogen distribution of senile septicemia patients with diabetes. Methods Eighty seven senile diabetic patients with septicemia from January 2004 to December 2008 were surveyed. Results Among 108 strains of isolated pathogens,gram-negative organisms accounted for 53.70% of isolates, while gram-positive organisms was 32.4% and fungi 13.9% .The invasive pathways of septicemia were respiratory system , urine system ,gastrointestinal tract,biliary tract,damaged skin and intravenous catheter detain .The commonest pathogens ausing septicemia were E.col(i21.3%),Coagulase negative staphylococcus(18.5%),Klebsiella pneumoniae(12.0%),Candida albicans (7.4%),Acinetobacter baumannii (5.6%).The ESBLs isolating rate was 47.8% in E.coli and 23.1% in Klebsiella pneumoniae.The isolating rate of methicillin-resistant Coagulase negative staphylococcus(MRCNS)was 100.0%. Methicillin- resistant Staphylococcus aureus (MRSA) and MRCNS were highly resistant to the commonly used antibiotics,but all susceptible to vancomycin and teicoplanin. Conclusion Septicemia in senile diabetic patients is very common .. Early isolation of pathogens and monitoring of resistance of bacteria to antibiotics is very important for rational use of antibiotics and infection control.
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