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《China Tropical Medicine》 2011-11
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Effects of extract of Isodon Lophanthoides var.gerardianus (Benth.) Hara on the production of TNF-α and the change of ultrastructure of liver cell in mice induced by concanavalin A

LI Xiao-hui,ZHU Chen-hen,LI Chang-qing,et al.(1.School of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,P.R.China)  
Objective To investigate effects of extract of Isodon Lophanthoides var.gerardianus(Benth.)Hara(LIVG) on the production of TNF-α and the change of ultrastructure of liver cell in mice induced by concanavalin A.Methods Fifty NIH mice were randomly divided into normal control group,model group,extract groups of LIVG(high-and 1ow-dosage),and cyclophosphamidum group(43mg/kg).In the experimental groups,mice received the extract of ILVG(18.20,4.55g/kg,respectively) by gastric perfusion or injected with cyclophosphamidum into its abdominal cavity daily at the first,the second,the third and fourth day afternoon.Excepts those in normal control group,mice in other groups were injected with Con A(dose of 20mg/Kg) via the tail vein at the first day morning of experiment,On the 5th day,mice were injected with Con A once again with the same dosage 2 hours after the drugs were administered.After 4 hours,the blood of eight mice in each group were obtained and the TNF-α activity was determined.The mice in each group were killed 8 hours later and the change of ultrastructure of the hepatocyte of mice was observede under electron microscope.Results It showed that contents of TNF-α in serum in both groups of LIVG were obviously lower than that of model group(P0.01,0.05),Histopathological change of ultrastructure of hepatocyte were alleviated in both groups of LIVG.Conclusion It suggested that the extract of LIVG possess the effects of protecting liver from immune injury in mice induced by concanavalin A by suppressing the production of TNF-α.
【CateGory Index】: R285.5
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