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《China Tropical Medicine》 2011-11
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Effects of extract of Isodon Lophanthoides var.gerardianus (Benth.) Hara on the production of TNF-α and the change of ultrastructure of liver cell in mice induced by concanavalin A

LI Xiao-hui,ZHU Chen-hen,LI Chang-qing,et al.(1.School of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong,P.R.China)  
Objective To investigate effects of extract of Isodon Lophanthoides var.gerardianus(Benth.)Hara(LIVG) on the production of TNF-α and the change of ultrastructure of liver cell in mice induced by concanavalin A.Methods Fifty NIH mice were randomly divided into normal control group,model group,extract groups of LIVG(high-and 1ow-dosage),and cyclophosphamidum group(43mg/kg).In the experimental groups,mice received the extract of ILVG(18.20,4.55g/kg,respectively) by gastric perfusion or injected with cyclophosphamidum into its abdominal cavity daily at the first,the second,the third and fourth day afternoon.Excepts those in normal control group,mice in other groups were injected with Con A(dose of 20mg/Kg) via the tail vein at the first day morning of experiment,On the 5th day,mice were injected with Con A once again with the same dosage 2 hours after the drugs were administered.After 4 hours,the blood of eight mice in each group were obtained and the TNF-α activity was determined.The mice in each group were killed 8 hours later and the change of ultrastructure of the hepatocyte of mice was observede under electron microscope.Results It showed that contents of TNF-α in serum in both groups of LIVG were obviously lower than that of model group(P0.01,0.05),Histopathological change of ultrastructure of hepatocyte were alleviated in both groups of LIVG.Conclusion It suggested that the extract of LIVG possess the effects of protecting liver from immune injury in mice induced by concanavalin A by suppressing the production of TNF-α.
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 HU Ying-jie, LAI Xiao-ping, LIU Zhong-qiu, ZHU Yu-tong, DENG Xue-long, LIU Ni, CHEN Jian-nan(Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China);Chemical components of Isodon lophanthoides var. gerardianus and their anti-hepatitis B virus effects[J];Chinese Traditional and Herbal Drugs;2005-11
2 NAGAO Yukiko,YE Mu-rong,LIN Chao-zhan,ZHU Chen-chen,LAI Xiao-ping(New Drug Research and Development Center,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Protective effect of Isodon lophanthoides var.gerardianus on acute hepatic injury induced by carbon tetrachloride in rats[J];China Journal of Chinese Materia Medica;2006-07
3 LIN Chaozhan,ZHU Chenchen,ZHONG Zhiyong,RONG Xianglu,XIONG Tianqin (College of Pharmacy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405);Protective Effect of Isodon lophanthoides var.gerardianus (Benth.) Hara on Hepatic Injury Induced by Concanavalin A in NIH mice[J];Traditional Chinese Drug Research & Clinical Pharmacology;2006-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZENG Fan-rong,ZU Xiang-xiu,YANG Guang,ZHU Hong-yan,DIN Jun,ZHANG Fei(Huainan Center for Disease Control and Prevention,Huainan,Anhui,232033,China);Analysis On Detectiing Data Of Anti-HBc IgM(+) Of The Serums From Chronic Hepatitis B Patients And Chronic A-symptomatic HBV Carriers[J];Anhui Journal of Preventive Medicine;2010-04
2 Zhang Zhaoru, Zhu Liyu, Chen Hong Chu zhou First People Hospital, Chu zhou 239000;Armillarisis A treating chronic hepatitis B With intrahepatic cholestosis[J];Anhui Medical Journal;2008-03
3 TIAN Xiao-peng,LI Wei-zu,YIN Yan-yan(Anhui Medical University,Hefei 230032,China);Protective effect of AMM on acute liver injury induced by carbon tetrachloride in mice[J];Anhui Medical and Pharmaceutical Journal;2011-01
4 DENG Chu-shu,LUO Li,ZHU Cheng-quan,YAN Yi-zhong,LIU Zhi-lan (Department of Infectious Disease ,the 421th Hospital of PLA, Guangdong Guangzhou 510318, China);Clinical Observation on Treatment of Chronic Hepatitis B with Injection of Matrini and IFNα-1b[J];Journal of Anhui Traditional Chinese Medical College;2003-04
5 Xia Yin,Sun Xibin (The Second Hospital of Nanjin,Jiangsu 210003 );Biochemical parameter in estimating chronic hepatic failure[J];JOURNAL OF BENGBU MEDICINAE COLLEGE;1999-05
6 HUA Yi zhang,SONG Wen qi,LI Xia,MAO Kui ying (Hospital of Anhui University,Hefei 230039,China);Hepatitis B vaccination in undergraduates and protection against hepatitis B[J];Journal of Bengbu Medicine College;2003-01
7 SHANG Li-li1,REN Kai-xiang2(1.Department of Infections Diseases,Bengbu Infections Diseases Hospital,Bengbu 233000;2.Department of Gastroenterology,Bengbu First People's Hospital,Bengbu 233000,China);Nucleic acid quantifying assay of hepatitis B virus and clinical significance[J];Journal of Bengbu Medical College;2007-05
8 LI Wei(Liver Branch,Fuyang 2nd People′s Hospital,Fuyang Anhui 236015,China);Peginterferon α-2a for treatment of chronic hepatitis B:a report and literature review of 2 cases[J];Journal of Bengbu Medical College;2010-10
9 WANG SHU-XIA,YAN ZHI-YONG,WANG LI-QIU, et al(Department of Radiotherapy,Linyi People's Hospital,Linyi 276003,China);INTEGRATION OF HBV X AND P GENES IN PBMCs IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA[J];Acta Academiae Medicinae Qingdao Universitatis;2006-03
10 Sheng Guoliang Xiaoshan District TCM Hospital,Hangzhou City,Zhejiang Province(311201);Therapeutic Effect of Xiaozheng Kangxian Decoction on 54 Cases of Liver Fibrosis of Chronic Hepatitis Ⅱ[J];Journal of Zhejiang College of Tcm;2005-01
China Proceedings of conference Full-text Database 6 Hits
1 GAO Qing-wei~* ZOU Han-fa KONG Liang LI Yong-xin LIU Sha WANG Bo WANG Ying-lan. *Dalian No.6 People's Hospital,Dalian 116001,China.;The experimental study of configurating an immunoadsorption column for hepatitis B virus[A];[C];2005
2 LI Qian TANG Ke-cheng YUAN Gui-yu YANG Ji-ming LI Hai HAN Gui-lan LIU Guo-wang Tianjin Infectious Disease Hospital,300192,China;The Efficacy of Nucleosides plus Artificial Liver Support System in Treatment of Patients with Chronic Severe Hepatitis[A];[C];2005
3 ;Study interrelated of Hepatitis B Virus Transmissl on from Mothers to Infants with HBV-DNA quantitive PCR[A];[C];2003
4 Lai Xiao-ping, Chen Jian-nan, Ye Mu-rong, Hou Shao-zhen, Li Geng- (Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510405 );The therapeutic Effect of Isodon lophanthoides var.gerardianus (Benth.) H.Hara on liver-injured animal models[A];[C];2006
5 Zhang Qi,Peng Jie,Dai Lin,Chen Yong-peng,Feng Xiao-rong,Guo Ya-bing,Hou Jin-lin.Deptartment of Infectious disease;the Affiliated Nanfang Hospital;Southern Medical University,Guangzhou 510515;China;Dynamic Changes of FibroScan on Patients with Chronic Hepatitis B[A];[C];2009
6 Wang Xiu~1,He Yumin~2 1.Wannan Medical College,Wuhu,Anhui,241001;2.Shanghai university of traditional Chinese medicine, shanghai,201203;Research on Mechanism and Curative Effect of Time-Selected Administration Ginsenoside[A];[C];2011
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Wang Yingfang,Wang Yuliang Postgraduate2000', Henan College of Traditional Chinese Medicine;Recent Development in the Experimental Study of Chinese Medication for Liver Injury[J];Journal of Henan College of Traditional Chinese Medicine;2003-01
2 DING Li-jun ZHOU Yan-fang LIN Nan (Chemical Department,Hanshan Normal University,Chaozhou,Guangdong 521041,China);Extracting of flavone from Rabdosiea Serrae Hara and its effects on scavenging of hydroxyl radicals[J];Food and Machinery;2004-03
3 WANG Xinxin,SUN Lin,LANG Zhen wei,et al You ' an Hospital, Shou Du Medical University , Beijing 100054, China;Expression of transforming growth factor-betal in human chronic hepatitis B[J];Chinese Journal of Gastroenterology and Hepatology;2004-03
4 Lian Xuefeng, Yi Murong, Huang Guiying, Zhou Xiaoling, Lai Xiaoping (Guangzhou University of Traditional Chinese Medicine, Guangzhou 510407);Effects of the Water Soluble Extracts of Isodon lophanthoides, I. lophanthoides var. gerardianus and I. serra on Anti-inflammation and live r-protection in Mice[J];Journal of Chinese Medicinal Materials;1996-07
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