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《Journal of Tropical Medicine》 2002-01
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Antioxidative ability of carboxyethylgermanium (Ge-132) on the alcoholism in rat

Zhou Ying, Shi Tongxing, Nie Muhai, Zhu Maosheng, Mai Suixia Guangzhou City Sanitary & Anti-Epidemic Station, Guangzhou 510080  
Objective To study the mechanism of the inhibition of lipid peroxidation caused by alcohol in vivo by carboxyethylgermanium (Ge-132).Methods SD rats were orally fed with alcohol at the dose of 10mg/kg, and Ge-132 at the dose of 100mg/L at the same time for three months.Results Results indicated that the contents of malondialdehyde (MDA) was decreased (P0.05) and the activities of superoxide dismutase(SOD), catalase(CAT) were increased in tissues and sera of the rats treated with alcohol+Ge-132 when compared with those treated with alcohol only (P0.05), but showed no significant differences when compared with untreated rats (P0.05).Conclusion The result indicated that the Ge-132 could reduce the harmful effect of over-dose alcohol to the animal by scavenging hydroxyl radical(OH·) and superoxide anion radical(O 2· -) through up regulating the activities of SOD and CAT.
【CateGory Index】: R965
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