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《Journal of Tropical Medicine》 2006-03
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Establishment of A Rat Model with Iron Deficiency Anemia(IDA)and A Survey on the IDA Related Indexes

YANG Zhen, LUO Hai-ji, LU Xiao-cui, DENG Hong, KONG Liang(Department of Nutrition and Food Hygiene, Southern Medical University, Guangzhou 510515,China)  
Objective To establish a rat model with iron deficiency anemia(IDA)by feeding the rat with a low iron diet and bleeding. To monitor the animal nutrition indexes and the change of related trace elements in internal organs. Methods SD rats were randomly divided into two groups (control and IDA group). The control group was fed with normal feed and water. The IDA group was fed with low iron (8 mg/kg) animal feed and distilled water. Low iron bait vessel was used in the IDA group. Hemoglobin was measured weekly till anemia was developed. When the IDA model was established, eight rats from each group were taken randomly and their organs were removed. The organ index (ratio between the weight of organ and the weight of the body) was measured. Concentrations of trace elements in the organs were also determined. Results In the IDA group, physical appearance of the rat, the behavioral change, and the body weight were dropped remarkably. The concentration of hemoglobin was also dropped to 86.9 g/L. The concentration of RBC and iron in whole blood dropped magnificently. The organ index of heart and spleen were higher in IDA group than in the control group. The concentration of Fe and Zn in brain and liver decreased obviously in IDA group, while the concentrations of Cu and Mn were higher in IDA group than in the control group. Conclusion A rat model with IDA was successfully established by feeding the rat with a low iron content diet and followed by bleeding. In this model, a number of indexes could be used to correlate with iron deficiency. Especially, the correlation between iron deficiency and the concentrations of some related trace elements in organs.
【CateGory Index】: R-332
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【References】
Chinese Journal Full-text Database 5 Hits
1 ;Wistar大鼠缺铁性性贫血模型的建立[J];Contemporary Medicine;2011-35
2 ZHU Hang1,HE Qiu-shi2,LU Yang3,LEI Lei1,LUO Hai-ji1(1.Department of Nutrition and Food Hygiene,Public Hygiene and Tropical Medicine School,Southern Medical University,Guangzhou 510515;2.Department of Nutrition and Food Detection,Institute of Hotel Management Technoligy,Qingdao 266100;3.Department of Physical Labor Hygiene and Occupational Disease,Public Hygiene and Tropical Medicine School,Southern Medical University,Guangzhou 510515,China);Protective Effects of Selenium-Enriched Yeasts on Mice with Liver Damage Caused by Iron Overloading[J];Journal of Tropical Medicine;2007-08
3 WANG Chao;ZHOU Yong;DU Bing;College of Food Science, South China Agricultural University;Infinitus(China) Co., Ltd.;;Evaluation on extracts from Lentinula edodes and Auricularia auricula-judae in improving nutritional anemia in rats[J];Journal of Food Safety & Quality;2013-05
4 YANG Hong-xia1,2,3,DU Yu-zhi1,2,WEI Li-xin1,2,LI Cen1,2,3(1.Northwest Plateau Institute of Biology,Chinese Academy of Sciences,Xi'ning 810008,China;2.Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation,Xi'ning 810008,China;3.Graduate University of Chinese Academy of Sciences,Beijing 100049,China);Effect of raw and processed iron powder and Qiwei Tiexie Pill on anemic mice[J];Chinese Traditional Patent Medicine;2011-08
5 HAN Yan-bin,PENG Liang,ZHAO Peng,LI Bin,ZHANG Jie-hong,QIN Hui-yan,YAO Si-yu,LI Feng-wen,HUANG Chao-pei(Guangxi Center for Disease Control and Prevention,Nanning 530028,China);Evaluation on donkey-hide glue oral solution Yunting licensing in improving nutritional anemia in rats[J];Chinese Journal of Health Laboratory Technology;2009-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 JI Feng~(1,2), LUO Xu-gang~1,LIU Bing~1,YU Shun-xiang~11.Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100094;2.School of Animal Science and Technology,Anhui Agricultural University,Hefei 230036);In vivo Study on Absorption of Manganese as Different Manganese Sourcesby Ligated and Perfused Intestinal Segments of Broilers[J];Journal of Anhui Agricultural University;2005-02
2 REN Hanyun; KOMATSU Norio; MIURA Yasusada ;LU Daopei (Institute of Hematology, Beijing Medical University 100044);CHANGES IN ERYTHROPOIETIN RECEPTOR AND GRANULOCYTEMACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR EXPRESSIONS DURING ERYTHROID DIFFERENTIATION OF PLURIPOTENT CELL LINE UT-7[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1997-03
3 GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation[J];Acta Academiae Medicinae Militaris Tertiae;2008-10
4 Li Lili Zhang Bin Xing Tingxian Ren Peitao(Changsha Institute of Agricultural Moilenization,Chinese Academy of Science,Changsha,410125)(Animal Sciences College,Hunan Agricultural University,Changsha)(Service Center for Feed Additive Technology,Chemical IndustryMinistry of P.R.Chinna,Jinan,250014);EFFECTS OF Fe - AMINO ACIDS COMPLEX ON PERFORMANCE OF SUCKLING PICS[J];Acta Zoonutrimenta Sinica;1995-03
5 ZHOU Gui-lian1,HAN You-wen2,XU Zi-wei3,LIU Min-hua3,DENG Bo3,XU Ying3(1.Institute of Animal Science,Guang Dong Academy of Agricultural Science,Guangzhou 510640,China;2.Collage of Animal Science,Northeast Agricultural University,Harbin 150030,China;3.Insti;BIOAVAILABILITY OF IRON IN DIFFERENT Fe SOURCES FOR RATS[J];Acta Zoonutrimenta Sinica;2002-02
6 ZHOU Gui - Han, HAN You - wen, TENG Bing, XU Zi - wei LIU Min-hua ,XU Ying,DENG Bo ,XU Hai - feng ( Institute of Animal Science, Guangdong Academy of Agricultural Science, Guangzhou 510640, China; College of Animal Science, Northeast Agricultural University, Harbin 150030, China; Institute of Animal Science, Zhejiang Academy of Agricultural Science, Hangzhou 310021, China);STUDY OF IRON ABSORPTION OF IRON AMINO ACID CHELATES: COMPARISON WITH THE AMINO ACID AND FeCl_2 MIXTORE WITH SAME MOLES CONCENTRATION AS THE CHELATES[J];Acta Zoonutrimenta Sinica;2003-03
7 SUN Tie-hu PIAO Xiang-shu~* GONG Li-min LI De-fa(National Feed Engineering Technology Research Center,China Agricultural University,Beijing 100094,China);Effects of Iron-Amino Acid Complex on Growth Performance and Related Parameters in Growing Pigs[J];Chinese Journal of Animal Nutrition;2006-01
8 WU Jian-she(Institute of Animal Husbandry and Veterinary Sciences,Beijing Academy of Agriculture and Forestory Sciences,Beijing 100081,China)GUO Yu-ming, ZHOU Yu-ping(College of Animal Sciences and Technology,China Agricultural University,Beijing 10009;STUDIES ON EFFECTS OF DIETARY IRON ON PERFORMANCE AND IMMUNE FUNCTION IN BROILER CHICK[J];ACTA ZOONUTRIMENTA SINICA;1999-03
9 XIAO Yan-feng1,WANG Ru-wen2,MEI Jian2,SONG Xin2,WU De-dong1,ZHENG Chun-li1.(1 Department of Pediatrics,the Second Affiliated Hospital of Medical College,Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China;2 China National Children Center,Beijing 100035,China);Effectiveness of lunch-iron fortified rice on students with iron deficiency anemia.[J];Chinese Journal of Child Health Care;2009-02
10 Qian Hongjuan, Pu Junhua, Wang Zhiyue;Influence of different iron source on growth of broilers[J];Feed Industry;2008-02
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 LIU Weilong1 ZHAN Xiuan1 WANG Yongxia1 QIE Yanzhao2 WU Rujuan1(1.Feed Science Institute,Zhejiang University,Hangzhou 310029,China;2.Beijing Challenge AgriculturalScience & Technology Co.,Ltd.,Beijing 100081,China);Dietary DL-selenomethionine Supplementation of Broiler Breeder Diets Affects the Meat Quality of the Progeny[J];Chinese Journal of Animal Nutrition;2011-03
2 XU Weiguang Department of Neurosurgery,the First Hospital Affiliated to Guangdong College of Pharmacy Correspondenc,Guangzhou 510080,China;Shengxuening for treatment effect of the senile anemia merger functional constipation[J];China Medicine and Pharmacy;2012-03
3 CHEN Xiuyun;HUA Jing;YANG Zuojun;WANG Xiaoxia;YANG Kailun;ZHANG Jie;College of Animal Science,Xinjiang Agricultural University;College of Animal Science and Technology,Beijing Agricultural University;Biotechnology College, Beijing Agricultural University;District Commission of Beijing's Changping District;Animal Husbandry and Veterinary Department,Beijing Vocational College of Agriculture;;Effects of Different Selenium Sources and Levels on Selenium Content,Antioxidant and Gene Expression in Liver of Breeder Roosters[J];Chinese Journal of Animal Nutrition;2013-09
4 TAO Xue-ling;Department of Gynecology and Obstetrics,Ouhai Third People' s Hospital;;Clinical effect of different ways of iron supplements used in iron deficiency anemia in pregnancy[J];Practical Pharmacy and Clinical Remedies;2013-11
5 WANG Chao;ZHOU Yong;DU Bing;College of Food Science, South China Agricultural University;Infinitus(China) Co., Ltd.;;Evaluation on extracts from Lentinula edodes and Auricularia auricula-judae in improving nutritional anemia in rats[J];Journal of Food Safety & Quality;2013-05
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