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《Journal of Tropical Medicine》 2006-03
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Establishment of A Rat Model with Iron Deficiency Anemia(IDA)and A Survey on the IDA Related Indexes

YANG Zhen, LUO Hai-ji, LU Xiao-cui, DENG Hong, KONG Liang(Department of Nutrition and Food Hygiene, Southern Medical University, Guangzhou 510515,China)  
Objective To establish a rat model with iron deficiency anemia(IDA)by feeding the rat with a low iron diet and bleeding. To monitor the animal nutrition indexes and the change of related trace elements in internal organs. Methods SD rats were randomly divided into two groups (control and IDA group). The control group was fed with normal feed and water. The IDA group was fed with low iron (8 mg/kg) animal feed and distilled water. Low iron bait vessel was used in the IDA group. Hemoglobin was measured weekly till anemia was developed. When the IDA model was established, eight rats from each group were taken randomly and their organs were removed. The organ index (ratio between the weight of organ and the weight of the body) was measured. Concentrations of trace elements in the organs were also determined. Results In the IDA group, physical appearance of the rat, the behavioral change, and the body weight were dropped remarkably. The concentration of hemoglobin was also dropped to 86.9 g/L. The concentration of RBC and iron in whole blood dropped magnificently. The organ index of heart and spleen were higher in IDA group than in the control group. The concentration of Fe and Zn in brain and liver decreased obviously in IDA group, while the concentrations of Cu and Mn were higher in IDA group than in the control group. Conclusion A rat model with IDA was successfully established by feeding the rat with a low iron content diet and followed by bleeding. In this model, a number of indexes could be used to correlate with iron deficiency. Especially, the correlation between iron deficiency and the concentrations of some related trace elements in organs.
【CateGory Index】: R-332
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