Prevention and Treatment of Bronchopulmonary Dysplasia with Pulmonary Surfactant in Premature Infants
QIAO Ping, YAN Yue-xiu, MO Wei-xiong, LIANG Xing-qun, TANG Min, XIAO Li, WANG Jiang-ping (The First People's Hospital of Zhaoqing City, Guangdong, Zhaoqing 526021, China)
Objective The aim of this study was to determine the therapeutic effect of pulmonary surfactant (PS) on the development of bronchopulmonary dysplasia (BPD) in premature infants. Method Twenty premature infants with respiratory distress syndrome (RDS) were divided into 2 groups. Eight subjects with RDS were selected into treatment and control groups. BPD occurrence rate as defined by the ventilator dependence rate, clinical parameters and arterial blood gas level in each group before and after treatment was observed. Result The mechanical ventilation time and the incidence of BPD in the PS group were significantly different from the control group (P0.05). The infants with BPD also had better arterial oxygen tension and saturation after PS treatment, and the difference was significant (P0.05, P0.01). Conclusion PS has both preventive and therapeutic effect on pre-mature infants with BPD. The pulmonary function can be improved by PS.
【CateGory Index】： R722.6