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《Journal of Tropical Medicine》 2008-10
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Clinical Significance of Measuring the Activities of Serum Cholinesterase(CHE) in Patients with Acute Massive Cerebral Infarction

HUANG Fan, YANG Jing, ZHONG Fei, XU Xue, MA Zhong-fu (Department of Neurology, the First Hospital of Sun Yat-sen University, Guangzhou 510080, China)  
Objective To study the alteration and clinical significance of serum cholinesterase (CHE) within the first 24 hours from onset in patients with acute massive cerebral infarction. Method The activities of CHE were detected within the first 24 hours from onset in 105 patients with acute massive cerebral infarction, and compared with those in 64 patients with less cerebral infarction and 32 healthy persons. Patients with massive cerebral infarction were examined with National Institutes of Health Stroke Scale (NIHSS) on admission and the modified Rankin scale score (mRS) at 3 months after admission. Result The activities of CHE in patients with massive cerebral infarction were lower than those in patients with less cerebral infarction and in healthy persons. The level of serum CHE was significantly negatively correlated with NIHSS and the modified Rankin scale score (mRS). Logistic stepwise regression showed that the decreasing activities of CHE was identified as one of independent risk factors for worse prognosis of acute massive cerebral infarction. Conclusion The decreasing degree of CHE in serum in patients with massive cerebral infarcts is associated with deterioration and prognosis.
【Fund】: 广东省自然科学基金(No.2004B33801006)
【CateGory Index】: R743.3
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