Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Effect of Compound Rehmannia Recipe on Apoptosis in Parkinson's Disease Rats

WANG Zhenhua,HE Jiancheng,ZHANG Chunyan  
Objective:To observe the effect of Compound Rehmannia Recipe(CRR) on apoptosis in Parkinson's disease(PD) rats.Methods:PD rat models were induced by injection of 6-hydroxydopamine(6-OHDA)into the right substantia nigra of the rats,and then were treated with CRR(4.14g/mL,2 mL/d).Meanwhile,the normal control group and the sham-operation group were established.The apoptosis of nerve cells in PD rats was observed and the effect of CRR on PD rats was observed.Results:Obvious apoptosis was found in PD rats,the number of cells with positive TUNEL staining and the expression of BCL-2 and Bax were increased,apoptotic features were obvious under electron microscope.CRR had an obvious improvement on the above changes.Conclusion:CRR exerts obvious inhibition on neuron apoptosis in PD rats.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved