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A Study of Spontaneous Pathologic Changes in Experimental Beagle Dogs

LUO Zhuoling,ZHANG Liqun,LI Wen,ZHANG Saixia,LIU Qide, HUANC Ren,CHENC Shujun(Guangzhou University of TCM,Guangzhou 510405, China; Guangdong Institute for Monitoring Experimental Animals,Guangzhon 510000,China)  
Routine clinical examination was carried on for 46 experimental Beagle dogs with the age of 10~12 months and histopathologic examination for 18 dogs taken randomly.The results showed that the con-tents of glutamic-pyruvic transaminase and glutamic oxaloacetic transaminase in part of the dogs were highand spontaneous pathologic changes occurred in the important organs, such as lung, kidney and brain. Theincidences of interstitial pneumonia, cerebral ependymitis and vascular infiltration were high. Cloudyswelling and vasular degeneration apppeared in part of hepatocytes and epithelial cells of renal tubules.It issuggested that the raising and management of the experimental animals should be strengthened and certainnon-infectious diseases be monitored so as to reduce the occurrence of spontaneous pathologic changeswhich may interfere with the result of experiment.
【Fund】: 国家科技部“九五”重点科技项目!96-A-23-06-06;;广东省科委重点科技攻关项目
【CateGory Index】: Q95-331
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