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《JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE》 2000-02
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Effects of Bushen Yizhi Decoction on Hippocampal Long_term Potentiation in Rat Model with Alzheimer's Disease

RAO Yan, LAI Shilong, HU Jingqing, WANG Qi (Senile Encephalopathy Institute,Guangzhou University of TCM,Guangzhou 510405,China)  
To explore the effects of Bushen Yizhi Decoction(BYD)on the hippocampal long_term potentiation (LTP) in rat model with Alzheimer's disease(AD),AD rat model was established by intraperitoneral injection of D_galactose and ibotenic acid injection into nucleus basalis of Meynert.Electrophysiological method was used to assess the changes of long_term potentiation of dentate gyrus.BYD groups were treated with gastric infusion of BYD for 4 weeks.The results showed that the differences of potentiation of excited postsynaptic potentials(EPSPs)were not significant among the five groups (P 0.05 ),and potentiation of population spike(PS)amplitude in BYD groups were significantly different from AD model group.It is suggested that BYD exerts an effect in improving hippocampal LTP in rat model of AD.
【Key Words】： ALZHEIMER'S DISEASE/TCD therapy DEMENTIA SENILE/TCD therapy KIDNEY_REINFORCING DRUGS/ther.use @BUSHEN YIZHI DECOCTION/pharmacology HIPPOCAMPUS/drug effects @SYNAPTIC TRANSMISSION/drug effects DISEASE MODELS ANIMAL RATS (original ar
【Fund】： 国家“九五”科技重点攻关项目! (NO :96 - 90 6 - 0 9- 0 2 ) ;; 国家医药技术创新博士项目! (NO :98-B - 13)
【CateGory Index】： R285
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【References】
Chinese Journal Full-text Database 7 Hits
1 MA Cheng, YAN Li-ping, SHEN Hong-mei (Key Acupuncture Laboratory of Jiangsu , Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu , 210029,China);Effect of Electrical Acupuncture on Long-term Potentiation of Excitatory Postsynaptic Potential of Rat Hippocampus[J];JOURNAL OF NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2003-03
2 LIU Yi-fan;Director:ZHANG Zhen-yu (Shandong University of Traditional Chinese Medicine ,Jinan 250014 ,China);Evaluation and prospects of study on treatment of Alzheimer's disease from kidney deficiency[J];Shandong Journal of Traditional Chinese Medcine;2001-09
3 Pan Jingqiang,Tan Hairong,Li Boping 1,Xiao Liuying,Han Chao (Guangzhou Institute of Traditional Chinese Medicine and Materia Medica,Guangzhou 510130; 1Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130);The progress of traditional chinese medicine on inhibiting D-galactose-induced pathologic animal model[J];Guangdong Pharmaceutical Journal;2001-05
4 ZHANG Kui hua 1, LAI Shi long 2, WANG Qi 2, CHENG Shu yi 2, CHEN Yun bo 2(1 Guangzhou Military Medical Institute, Guangzhou Military Region, Guangzhou 510507, China; 2. DME Center, Guangzhou University of TCM, Guangzhou 510507, China);Improving effects of BUSHEN YIZHI RECIPE on orientation sail learning and memory in model rat with Alzheimer's disease[J];Chinese Traditional and Herbal Drugs;2002-10
5 ;Rcseach and Development of Bushen Decoction on promoting Intelligence and Anti-AD[J];Study Journal of Traditional Chinese Medicine;2004-05
6 ZHOU Jieming~1, LAI Shilong~2, RAO Yan~2, HU Jingqing~2 (1. China Institute for Drugs & Biogicals Control, Beijing 100050; 2. DME Center, Guangzhou University of TCM, Guangzhou 510405; 3. Center for Clinical Evaluation, China Academy of Traditional Chinese Medicine, Beijing 100700);Effect of BushenYizhi Prescription on Long-Term Potentiation in Hippocampus of Ovariectomized Rats[J];Traditional Chinese Drug Research & Clinical Pharmacology;2003-06
7 Liang Xiaochun Peking Union Medical College Hospital, Beijing 100730, China Translated by Duan Shumin;The TCM Kidney-nourishing Method for Protection of Brain in Patients with Diabetic Encephalopathy[J];中医杂志(英文版);2007-02
【Citations】
Chinese Journal Full-text Database 2 Hits
1 HU Jingqing, LAI Shilong, WANG Qi, LIANG Weixiong, XIE Hong (DME Center,Guangzhou University of TCM,Guangzhou 510405,China);Protective Effect of Bushen Yizhi Decoction on Brain Cholinergic System in Rat Model with Alzheimer's Disease[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-03
2 Zhang Xi;Zhang Baozun;Yang Xinping et al(Neurology Dept,General Hospitai of Beijing Armed Forces, Beijing 100700);Learnging and memory impairment in aging rat model induced by D-galactose[J];CHINESE JOURNAL OF GERONTOLOGY;1996-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SUN Yong-ye,MA Ai-guo,JIA Yi-na,ZHANG Xiu-zhen(Institute of Nutrition ,Medical College of Qingdao University,Qingdao 266021,China);The Effect of Gynostemma Pentaphyllum Extract on DNA Damage of Aging Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
2 JIANG Changqing, LIU Guangyi, GUO Zongjun, et al Department of Pathology, Qingdao Municipal Hospital, Qingdao 266011;A STUDY OF TREATMENT ON COGNITION DISORDER OF RATS BY USING ESTROGEN SUPPLEMENT THERAPY[J];Acta Acadimae Medicinae Qingdao;2001-02
3 Mao Mu hua,Wu Ji yun(Department of physiology,JinggangShan Medical School,JiAn,JiangXi,343000);Effect of little doses sodium nitroprusside on learning and memory of mice[J];Journal of Jinggangshan Medical College;2001-06
4 WANG Hua qiao, YUAN Qun fang,XIE Yao,LI Guang wu,YAO Zhi bin ( Department of Anatomy & Neurobiology,Zhongshan Medical College,Sun Yat-sen University,Guangzhou 510080, China);Effect of TA9902 on Choline Acetyltransferase Neurons in Senescence-accelerated Mouse[J];Progress of Anatomical Sciences;2003-02
5 Li Yaming1,Zhu Cuiqing2Lin Shuimiao3,et al.1 Huadong Hospital,Shanghai 200040,China;2 National Key Laboratory of Neurobio logy,Medical College,Fudan University,3 Geriatrics Institute,Shanghai Uni versity of Traditional Chinese Medi cine and Pharm;ESTABLISHMENT OF A RAT MODEL WITH ALZHEIMER' S DISEASE[J];Gereatrics & Health Care;2001-04
6 Wang Zhonglin,Gu Yihuang,Jiao Ruiqing △,et al. (Second Clinical College,Nanjing TCM University; △Biochemistry Department,Nanjing University);Changes of Synaptic Protein of Hippocamp in Mouse Aging Model Caused by D-galactose[J];JOURNAL OF NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1997-04
7 LAI Shilong, HU Jingqing (Senile Encephalopathy Institute, Guangzhou University of TCM, Guangzhou 510405 ,China);Several Key Points for the Prevention and Treatment of Alzheimer's Disease in Traditional Chinese Medicine[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
8 LAI Shilong, HU Jingqing, WANG Qi, WEN Zehuai, LIANG Weixiong (Senile Encephalopathy Institute,Guangzhou University of TCM,Guangzhou 510405,China);Preventive Effect of Bushen Yizhi Decoction on Learning and Memory in Rat Model with Alzheimer's Disease[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
9 HU Jingqing 1, LAI Shilong 1, WANG Qi 1, LIANG Weixiong 1, XIE Hong 1, ZHENG Gaofei 2 (1.Senile Encephalopathy Institute, Guangzhou University of TCM, Guangzhou 510405, China;2.Lab of Electromicroscope, Guangzhou University of TCM, Guangzhou 5;Bushen Yizhi Decoction for the Inhibition of Pathological Reconstruction of Hippocampal Synapse in Rat Model with Alzheimer's Disease[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-02
10 ZHOU Lequan, DING Shengyuan, LUO Rongjing, CHEN Jingping, SU Wen, LIN Ruishan (Basic Medical Science School,Guangzhou University of TCM,Guangzhou 510405,China);Effect of Yin-Deficiency on Learning and Memory of Aging Model Rats[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Fang Zhaohui Cui Yiwu Cheng Xiaowen Cheng Shuangping (Affiliated Hospital of Anhui TCM College,Hefei,230031);EFFECTS OF D GALACTOSE CATARACTS IN RATS WITH TEA PIGMENT[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1997-03
2 Wang Miqu (Chengdu University of TCM, Chengdu 610075)Zeng Xiangguo(Huaxi Medical University)Lin Qiao (The Secondary Institute of Agriculture and Animal Husbandry in Chengdu);Priliminary Report on Testicular Pathologic Pictures in Rats Suffering Congenitle Kidney Dificiency[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1998-02
3 Liao Han; Zhang Qiujun; Ma Jun; et al.(Shanghai University of Chinese Traditional Medicine, Shanghai 200032 );Effect of Bac-Chun-Fang on Cyclic Nucleotide Content in Tissues of Old Rats[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1997-04
4 Xiong Wen,Wang Youlian,Li Xiaomei,et al(Department of Biochemistry);Glutamate excitotoxicity on primary cultured hippocampal neurons[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1997-06
5 Liu Xiao - yan et al ( Fundamental College of Beijing University of Traditional Chinese Medicine, Beijing);Research of the Relation of Modulation Mechanism of “Kidney Corresponds to Winter” in TCM and Hypothalamus G Protein[J];China Journal of Traditional Chinese Medicine and Pharmacy;2002-11
6 Liu Xiaoyan et al (Beijing University of TCM);Theory of “ The Kidney is Correspondent to Winter" and its Relation to Gonad Axis[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-09
7 WANG Xue Mei △, FU Hong, LIU Geng Xin (Institute of Integrated of Traditional Chinese and Western Medicine, Peking University, Beijing 100034,China);Effect of Herba Epimedii and Fructus Lycii on mitochondrial DNA deletion, activity of respiratory chain enzyme complexes and ATP synthesis in aged rats[J];Journal of Beijing Medical University;2002-01
8 HE Qihua, ZHOU Huifang, XUE Bing, NIU Dongbin, WANG Xiaomin △ (Neuroscience Research Institute, Peking University, Beijing 100083,China);Neuroprotective effects of Tripterygium Wilforddi Hook F monomer T_(10) on glutamate induced PC12 cell line damage and its mechanism[J];Journal of Beijing Medical University;2003-03
9 Liao Fangzheng, Chen Jianzong, Zhao Xuejun(Chengdu University of Traditional Chinese Mdeicine(Chengdu 610075);The Clinical Observation to 61 Cases of Senile Dementia Treated with Invigorating the Kidney and Activating Blood[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;1996-04
10 Wang Yu, Luo Yongzhen, Bai Hua et al Chengdu University of TCM (Chengdu,610075,China);Influence of IL-2 Activity of Filial Generation Mice by Terroring Pregnant Mother Mice[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1998-01
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 Li Zhiqiang, Zhao Guoping Medical College, Jinan University,Guangzhou(510632);Thinking of Chen Siduo’s Treatment of Dullness and Morbid Forgetfulness[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-03
2 CHU Song-ling,WANG Xue-mei,LIU Geng-xin (Institute of Integrated Traditional and Western Medicine, First Hospital of Peking University, Beijing 100034, China);Effects of Jiawei Wuzi Yanzong Recipe on Space Learning and Memory Result of Dysmnesia Mice[J];Tianjin Journal of Traditional Chinese Medicine;2006-03
3 Lin Ni1,Pan Jing-qiang2,Xiao Liu-ying2,Tan Hai-rong2,Lin Jie-ru1,Zheng Lin-ying1,Li Bo-ping1 1Department of Pharmacy, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou 510130, Guangdong Province, China;2Department of Pharmacology, Guangzhou Institute of Traditional Chinese Medicine and Materia Medica, Guangzhou 510130, Guangdong Province, China;Effect of glycyrrhiza against impaired glucose tolerance in rats induced by D-galactose[J];Chinese Journal of Clinical Rehabilitation;2006-07
4 Zhou Yan1,Tan Hai-rong2,Pan Jing-qiang2,Lü Jun-hua3,Zhang Shi-ping3,Xiao Liu-ying21Department of Pharmaceutics,Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130,Guangdong Province,China; 2Guangzhou Institute of Traditional Chinese Medicine & Materia Medica,Guangzhou 510130,Guangdong Province,China;3Department of Pharmacy,Jinan University,Guangzhou 510632,Guangdong Province,China;Inhibitive effects of glycyrrhizic acid on aldose reductase activity in rats induced by D-galactose[J];Chinese Journal of Clinical Rehabilitation;2006-19
5 PAN Jing-qiang ,XIAO Liu-ying ,HAN Chao ,TAN Hai-rong ,QING Fang .JIANG Yan-mei, LIANG Li-guo (Guangzhou Institute of Traditional Chinese Medicine & Materia Medica Guangzhou,510130,China;Dept of pharmacy,Guangdong College of Pharmacy Guangzhou, 510240, China);Effects of Gegenqinlian Decoction on antagonizing impaired glucose toler-ance in D-galactose-induced rats[J];Guangdong Pharmaceutical Journal;2004-01
6 ZHONG Yi,TAN Hai-rong,PAN Jing-qiang,XIAO Liu-ying. Department of Pharmacy,Second Affilliated Hospital of Guangzhou Medical College,Guangdong 510260,China;Puerarin inhibits the formation of advanced glycation endproducts and enhances insulin susceptibility in D-galactose-induced rats[J];Chinese Remedies & Clinics;2007-08
7 Wang Xiaoying1,Xiao Liuying2,Pan Jingqiang2,Deng Shuzhen3 (1.Department of Pharmacy,Guangzhou Hospital of Traditional Chinese Medicine,Guangdong Province,Guangzhou,Guangdong,China 510130; 2.Guangzhou Institute of Traditional Chinese Medicine &Materia Medica,Guangdong Province,Guangzhou,Guangdong,China 510130; 3.Guangdong Institute of Medicine,Guangzhou,Guangdong,China 510224);Effects of Glycyrrhiza on Rats with Diabetes Mellitus Induced by D-Galactose[J];China Pharmaceuticals;2007-13
8 ZHANG Kui-hua 1, LAI Shi-long 2, WANG Qi 2, CHENG Shu-yi 2, CHEN Yun-bo 2 (1.Guangzhou Military Medical Institute, Guangzhou 510507, China; 2. DME Center, Guangzhou University of TCM, Guangzhou 510507, China);Effects of BUSHEN YIZHI DECOCTION on interspace explore learning and memory in rat model with Alzheimer's disease[J];Chinese Traditional and Herbal Drugs;2002-12
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 陈长生，徐勇勇，曹秀堂;Study on the Power of Paired t-test[J];Chinese Journal of Health Statistics;1996-06
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