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《JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE》 2000-02
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Bushen Yizhi Decoction for the Inhibition of Pathological Reconstruction of Hippocampal Synapse in Rat Model with Alzheimer's Disease

HU Jingqing 1, LAI Shilong 1, WANG Qi 1, LIANG Weixiong 1, XIE Hong 1, ZHENG Gaofei 2 (1.Senile Encephalopathy Institute, Guangzhou University of TCM, Guangzhou 510405, China;2.Lab of Electromicroscope, Guangzhou University of TCM, Guangzhou 5  
To study the effects of Bushen Yizhi Decoction (BYD) on the pathological reconstruction of synapse, morphometry was applied for the quantitative analysis of synapse in molecular layer of hippocampal dentate gyrus in rats with Alzheimer's disease (AD). AD rat model was established by intraperitoneral injection of D-galactose and ibotenic acid injection into nucleus basalis of Meynert. The results showed that the numerical density (ND) of the synapse was significantly increased while the surface density (SD) and average area were decreased in the synaptic contact zones in BYD group as compared with the AD model group (P 0.01 ). Meanwhile, there was no significant difference in ND, SD and average area between BYD group and normal control group (P 0.05 ).It is suggested that BYD could inhibit the pathological reconstruction of hippocampal synapse in AD rats, and this may be one of the neurobiological mechanisms of BYD for the improvement of learning and memory.
【Key Words】： ALZHEIMER'S DISEASE/TCD therapy DEMENTIA SENILE/TCD therapy KIDNEY-REINFORCING DRUGS/ther. use @BUSHEN YIZHI DECOCTION/pharmacology SYNAPSES/drug effects DISEASE MODELS ANIMAL RATS (original article on page 113)
【Fund】： “九五”国家科技重点攻关项目! (编号 :96 - 90 6 - 0 9- 0 2 )
【CateGory Index】： R285
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