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Effect of Local Arterial Infusion of β_elemene on Breast Cancer Tissue Inhibition and Cell Apoptosis and Proliferation

TAN Min, GUO Zhitao, SHI Lingchun, WANG Bo, XIAO Chumei, ZHANG Weibing (The Second Affiliated Hospital, Guangzhou University of TCM, Guangzhou 510120, China)  
The effect of local arterial infusion of β_elemene on breast cancer tissue inhibition and cell apoptosis and proliferation was observed. The deoxyribonucleotide and labelling method mediating by end transferase and the immunohistochemical assay for cell nucleus antigen (PCNA)were employed to observe the apoptosis index (AI),cell division index and PCNA index. The mass of breast cancer was also observed.The breast cancer samples were taken from 14 cases receiving preoperative local arterial infusion of β_elemene (the treatment group) and 17 receiving operation only (control group ). The results showed that AI in the treatment group ( 7.97±1.50 ) was higher than the control group ( 2.26±0.49 ) (P 0.01 );the difference of PCNA index and division index were not significant between the treatment group ( 44.54±9.99 , 3.92±1.44 respectively) and the control group ( 42.80±6.78 ,3.88±1.08 respectively) (P 0.05 ). There is negative correlation between AI and the reduction of mass in the treatment group by degree relative analysis (r=_ 0.508 ).It is concluded that preoperative local arterial infusion of β_elemene can reduce the mass and its possible mechanism is by inducing breast cancer cell apoptosis.
【Fund】: 国家中医药管理局资助课题! (编号 :97Y0 2 8)
【CateGory Index】: R737.9
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