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《JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE》 2000-03
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Anti_HBV Effect of Phyllanthus Simplex Extracts in Vivo and in Vitro

HUANG Zhengchang, DENG Xuelong, ZHU Yutong, ZHANG Meiyi, LIU Ni, LI Fengxian (Tropical Medicine Institute, Guangzhou University of TCM, Guangzhou 510405, China)  
Anti_HBV effect of water extract and alcohol extract of Phyllanthus simplex Retz. from Taiwan was investigated in vivo and in vitro by means of 2215 cell strain and duckling infected with DHBV. The results showed that the water extract and alcohol extract had a certain inhibitory effect on HBsAg, and the alcohol extract showed no inhibitory effect on HBeAg. In vivo, the water extract at the dosage of 10g.kg -1 .d -1 and 5g.kg -1 .d -1 had an obvious inhibitory effect on DHBV_DNA on the fifth and the tenth day during treatment and the third day after treatment, while the alcohol extract showed no above effect. It is indicated that the water extract of Phyllanthus simplex Retz. exerts an anti_HBV effect.
【Key Words】: PHYLLANTHUS SIMPLEX RETZ. FROM TAIWAN/pharmacology @PHYLLANTHUS AMARUS/pharmacology HEPATITIS B VIRUS DUCK/drug eff. @2215 CELL LINE/ drug eff. DISEASE MODELS ANIMAL DUCKS
【CateGory Index】: R285
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