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《Journal of Guangzhou University of Traditional Chinese Medicine》 2001-04
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Effect of Shema Zhichuan Liquid on Cyclic Nucleotide in Lung Tissue of Rat Models with Asthma

LIU Xiaohong 1, LIAO Huili 1, LIANG Zhiying 1, CHEN Zhixi 2, ZHOU Minglu 1 (1.The Fifth Sector of Internal Medicine, Guangzhou University of TCM, Guangzhou 510405, China; 2. Guangzhou University of TCM, Guangzhou 510405, China)  
Objective To explore the mechanism of Shema Zhichuan Liquid (SZL) for asthma. Methods Forty rats were allocated to normal control group (Group A), model group (Group B),western medicine group (Group C) and SZL group (Group D). Radioimmunoassay was used to observe the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) and the ratio of cAMP/cGMP.Results After treatment, cAMP level and cAMP/cGMP ratio were increased and cGMP level decereased in Group C and Group D as compared with Group B (P 0.05). The difference of cAMP/cGMP ratio between Group C and Group D was not significant.Conclusion SZL can relieve asthma by correct the imbalance of cAMP/cGMP ratio and inhibit the infiltration of inflammatory cells.
【Key Words】: SHEMA ZHICHUAN LIQUID/pharmacology SHEGAN MAHUANG DECOCTION/therapeutic use ASTHMA/TCD therapy ADENOSINE CYCLIC MONOPHOSPHATE GUANOSINE CYCLIC MONOPHOSPHATE
【CateGory Index】: R285.5
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