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《Journal of Guangzhou University of Traditional Chinese Medicine》 2002-02
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Effect of Interleukin-6 on the Pathogenesis of Postmenopausal Osteoporosis

WEI Hewei, HOU Shuli, GONG Yu, LI Tongming, HU Biaolun, LIU Qingsi(l. Doctorate Graduate of Grade 2000, Guangzhou University of TCM, Guangzhou 510405, China; 2. Guangdong Qingyuan Hospital of TCM, Qingyuan 511500, Guangdong, China; 3. Guangzhou University of TCM, Guanzhou 510405, China)  
[ Objective] To explore the effect of interleukin-6 (IL - 6) on the pathogenesis of postmenopausal osteoporosis (PMOP). [Methods] According to the result of bone mineral density (BMD) scanning of lumbar vertebrae, 104 women were allocated to three groups. Thirty-one cases of PMOP was assigned to Group A, 37 postmenopausal women without osteoporosis to Group B and 36 healthy premenopausal women to Group C. Serum levels of IL-6, estrogen (E2) and bone gal protein (BGP) were determined by radioimmunoassay method. [Results] Serum level of IL-6 was higher in Group A and Group B than that in Group C and higher in Group A than that in Group B. A multiple regression analysis in Group B showed that IL-6 level was correlated negatively with BMD and estrogen, positively with BGP and had no correlation with age. [Conclusion] The pathogenesis of PMOP is related to the high level of IL-6 and the decrease of estrogen level.
【Key Words】： OSTEOPOROSIS POSTMENOPAUSAL/etiology INTERLEUKIN-6/blood ESTRADIOL /blood
【CateGory Index】： R58
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