Treatment of Kidney-reinforcing and Blood-nourishing Herbs for Anovulatory Sterility:Effect and Mechanism

WANG Bingjie, HUANG Haihong (Zhongshan Bo'ai Hospital of Guangdong Province, Zhongshan 528403, Guangdong)  

To observe the effect of kidney reinforcing and blood nourishing herbal medicines in treating anovulatory sterility (AS) and its mechanism. Two hundred and seventy six cases of AS with hypopituitarism confirmed by the examination of blood sexual hormones were divided into three groups to receive the treatment of promoting ovulation. Group A was treated with modified Zhenwu Decoction and Reinforcing Qi and Nourishing Yin Powder (one dose per day) from the third day of menstrual cycle (MC) to the ovulating day; Group B with clomiphene (50mg/d) from the fifth day of MC, with human chorionic gonadotrophin (HCG) added, 10?000?U im in the day of follicle maturity and Group C with human menopausal gonadotrophin (HMG) 25 U/d im from the eighth day of MC and then with HCG added, 10 000 U im in the day of follicle maturity. After treatment, the cases were asked to have sexual intercourse for three nights. Ovulation time was monitored by ultrasound B imaging for one time every other day until follicle became maturity (1 8?cm×1 8?cm).Early pregnancy was detected by HCG test.Ninety three MC were ovulatory among 167 MC in Group A, the ovulation rate being 55 68%; 182 among 230 in Group B , the rate being 79 13% and 88 among 134 in Group C , the rate being 65 67%. Multisample χ 2 test showed that the ovulation rate in Group A was lower than that in Group B and Group C (χ 2=9 345, P0 01). As for early pregnancy, 54 (32 33%) MC were positive in Group A, 50 (21 73%) in Group B and 48 (35 82%) in Group C. The pregnancy rate in Group A was higher than that in Group B and similar to that in Group C (χ 2=9 7173,P0 01). Classification of endometrium showed that the percentage of endometrium type A was 80 80%, 82 80% and 40 86% in Group A, Group B and Group C respectively. This indicates that the endometria of Group A and Group B are apt for implantation of ovum.[Conclusion]Ovulation promoting action of kidney reinforcing and blood nourishing herbal medicines is coordinated with the conception of endometrium and lead a high pregnancy rate, which may be credited to the holistic regulation of kidney tiangui chongren uterus axis function.

【Key Words】： INFERTILITY FEMALE/TCD therapy OVULATION/drug effects ENDOMETRIUM/ drug effects REINFORCING KIDNEY NOUR BLOOD
【CateGory Index】： R271.14

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