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《Journal of Guangzhou University of Traditional Chinese Medicine》 2002-04
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Effect of Bao Xin Kang on Cyclic Nucleoside Phosphate Level in Vascular Smooth Muscle of Rats with Myocardial Hypertrophic Heart Failure

HUANG Yanshou, XIAN Shaoxiang, YANG Hui, ZHOU Minglu, CHEN Zhixi(The First Affiliated Hospital, Guangzhou University of TCM, Guangzhou 510405, China)  
[Objective] To investigate the effect of Bao Xin Kang (BXK) on levels of cyclic adenosine monophosphate (cGMP) and cyclic guanosine monophosphate (cAMP) in vascular smooth muscle of rats with myocatdial hypertrophic heart failure and to explore its mechanism. [Methods] Fifty rats were randomly allocated to five groups: normal control group (Group A) , model group (Group B) , digoxin group (Group C), large - dose BXK group (Group D) and small - dose BXK group (Group E). Rat models with myocardial hypertrophic heart failure were established by subcutaneous injection of isoprenaline for 13 days. Radioimmunoassay was used to measure the levels of cAMP, cGMP and the ratio of cAMP/cGMP in vascular smooth muscle. The body weight and the weight of heart, liver and lung were measured and his-tomorphologic features of heart, liver and lung also examined. [Results] The levels of cAMP and cGMP and the heart index (heart weight /body weight) and the liver index (liver weight/body weight) in Group B were increased as compared with those in Group A (P 0.01); the levels of cAMP and cGMP in Group E and the heart index and the liver index in Group D and Group E were decreased as compared with those in Group B(P0.05orP0.01). And BXK could also improve the histomorphologic features of heart and liver. [Conclusion] BXK exerts a better effect in preventing and treating experimental myocardial hypertrophic heart failure and its mechanism may be related to the regulation of the levels of cAMP and cGMP.
【Key Words】： HEART FAILURE CONGESTTVE/pathology HEART FAILURE CONGESTIVE/TCD therapy BAG XIN KANG/therapeutic use ADENOSINE CYCUC MONOPHOSPHATE/analysis GUANOSEVE CYCLIC MONOPHOSPHATE/analysis AORTA/drug effects
【CateGory Index】： R285.5
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 WANG Peiyong; PANG Yongheng; WAN Guohua; CHANG Yingzi; SU Jingyi; TANG Chaoshu (Institute of Cardiovascular Research, Beijing Medical University, Beijing 100083);ALTERATIONS OF Ca~(2+) TRANSPORT IN MITOCHONDRIA ISOLATED FROM ISOPROTERENOL INDUCED HYPERTROPHIC MYOCARDIUM[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1997-05
2 Feng Fang Tutor. Lo Sing;THE EFFEETS OF ILEXONIN A ON CARDIAC FUNCTION AND HEMODYNAMICS[J];;1986-02
3 CHEN Yupeng , XIAN Shaoxiang, HUANG Yanshou( Dept. of Angiocardiopathy , the First Afiiliated Hospital t Guangzhou University of TCM, Guangzhou 510405, China);Pharmacodynamic Study of Bao Xin Kang in Rabbits with Cardiac Insufficiency[J];Journal of Guangzhou University of Traditional Chinese Medicine;2002-01
4 Zhang Gui sheng,Jin De shan,Li Jian hua,Li Hong,Qiu Hong wei,Zhou Yong shuang,Gao Rong,Gao Ru xin,Li Long gui(The 264 Hospital of PLA,Taiyuan 030001);THE CHANGE OF PLASMA CYCLONUCLEOTIDE,ATRIAL NATRIURETIC FACTOR AND NOREPINEPHRINE IN PATIENTS WITH CONGESTIVE HEART FAILURE AND ITS SIGNIFICANCE[J];SHANXI MEDICAL JOURNAL;1997-05
5 Li Kemin;Za Zuguang;Cui Pukun;Xie Ran and Jiang Bingjun (Department of Cardiovascular Diseases,Bengbu First People's Hospital,Anhui 283000);Changes and significance of cyclonucleotide in plasma with congestive heart failture[J];CHINESE JOURNAL OF THE CARDIAC FUNCTION;1994-03
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Chen Jin, Hu Da-yi, Zhang Lin, et al. (Heart Centre, Beijing Chaoyang Hospital Affiliated to The Capital University of Medical Sciences100020) (People's Hospital Beijing University, Beijing 100044);The Clinical Effect of Treatment with Carvedilol in Chronic Heart Failure[J];Chinese Journal of Medicinal Guide;2003-05
2 Lei Weiwei, Department of Electron Microscopy Xian Shaoxiang; Ding Youqin; Qiu Zhuoyi; Lu Liping; Ou Ming, Department of Internal Medicine, Affiliated Hospital Lai Shilong, Training Center of DME Wang Ningsheng, Institute of Clinical Pharmacology;Protective Effects of Ilexonin A on Cardiac Muscle in Rabbits with Experimental Chronic Congestive Heart Failure Under Electron Microscope[J];;1990-03
3 Jia Keliang Lin Bingliu Chen Zhixi Laboratory of Nuclear Medicine Luo Rongjing Department of Physiology Ou Ming Qiu Zhuoyi Yu Xiuling Department of Internal Medicine;Action of Ilexonin A on Calcium Fluxes in Rabbit Myocardium[J];;1991-01
4 Zhou Lequan huo Rongjing Tan Lincai Chen Jiewen Department of Physiology;Effect of Introventricular Injection of Ilexonin A on Arterial Blood Pressure and Heart Rate[J];;1991-04
5 Jia Keliang Chen Zhixi Lin Bingliu Laboratory of Nuclear Medicine Qiu Zhuoyi Ou Ming Department of Internal Medicine;Effects of Ilexonin A on Cyclic Nucleotides in Isolated Rabbit Myocardium and Vascular Smooth Muscle[J];;1992-02
6 HUANG Yanshou,XIAN Shaoxiang, ZHOU Minglu, YANG Hui, CHEN Zhixi(The First Affiliated Hospital, Guangzhou University of TCM, Guangzhou 510405, China);ECFect of Yang Xin Kang on Plasma Endothelin and Calcitonin - Gene Related Peptide Levels in Rats with Myocardial Hypertrophy Heart Failure[J];Journal of Guangzhou University of Traditional Chinese Medicine;2002-01
7 Chen Gencheng;Yang Zhimin; Hunag Peixin; Huangyan Liu Maocai(The Second Affiliated Hospital);Effect of Ilexonin A on Blood Pressure of Experimental Hypertensive Cerebral Hemorrhage in Rats[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1996-Z1
8 WANG Xing-Wang 1 ,CHEN Chang-Xun 2 ,FANG Tai-Hui 3 ,YANG Lan 2 ,YANG Xing-Kui 2 1 Technical Center, Jinling Pharmaceutical Company, Limited, Nanjing 210009; 2 Pharmacology Department, Shanghai University of Traditional Chinese Medicine, Shanghai 200032; 3 Pharmacology Department, Nanjing University of Traditional Chinese Medicine, Nanjing 210029,China;Experimental Studies on Mailuoning Injection Against Myocardial Ischemia[J];Chinese Journal of Natural Medicines;2004-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhou Yixuan,Dai Xiaohua,Li Chonghui,Wang Ling, Zhang Nianzhi,Gu Jianxia,Liang Xinglun (The First Affiliated Hospital,Anhui College of TCM,Hefei 230031);42 CASES OF ISCHEMIC HEART FAILURE TREATED BY GINSENG INJECTION[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1999-05
2 Liao Han; Zhang Qiujun; Ma Jun; et al.(Shanghai University of Chinese Traditional Medicine, Shanghai 200032 );Effect of Bac-Chun-Fang on Cyclic Nucleotide Content in Tissues of Old Rats[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1997-04
3 Sun Chcngwen,Lǚ Wenwei, Lei Chunli,Wu Yan,Chen Yu)(Dept.of physiogy; Dept.of physiologcal Central lad.,Basic College of Med. Sci.;Elect roph ysiological Lab.of the First Teaching Hospital);Effects of Astragal us saponins on experimental heart fail ure([J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1994-02
4 Hu Yuanhui ( Beijing University of Chinese Medicine, Beijing);Effects of Xinfukang Oral liquid on Activity of Calcium-ATPase and SDH in Rat with experimental Congestive Heart Failure[J];China Journal of Traditional Chinese Medicine and Pharmacy;2000-02
5 ZHANG Zhi-xia1 ZHANG Yi-xin2 LI Guo-chuan2 WU Di2 MIAO Hui2 WEI Cui-ping2(1The fourth hospital of Shijiazhuang,Shijiazhuang 050011,China;2College of TCM,Hebei Medical University,Shijiazhuang 050091,China);Effect of RenshenQiangxin Diwan on content of TNF-α and IL-1 in serum of rats with congestive heart failure[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
6 ZHOU Guo ying,LIN Song bo,LI Cui yun,et al\;(Affiliated People′s Hospital,FCTCM,Fuzhou,Fujian 350003,China);Study on Indexes of Cardiac Function in Both QI Deficiencyand YIN Deficiency Syndromes of Primary Hypotension[J];Journal of Fujian College of Traditional Chinese Medicine;2001-04
7 Zou Xianggu ng Zhaohan * (Fujian Institute of TCM & Pharmacology; Armed Police General Hospital of Fujian Province);Relationship Among TCM Symdrome,Pulse-Cardiac Function & Cardiac Function Grading in Chronic Left Cardiac Insufficiency[J];JOURNAL OF FUJIAN COLLEGE OF TRADITIONAL CHINESE MEDICINE;1996-03
8 Ou Ruiming, Chen Yunxian, Zhong Xueyun, et al. Department of Internal Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080;Effects of G-CSF on myocardial infarction in experimental rats[J];Guangdong Medical Journal;2002-11
9 SHEN Xian-chun1,TAO Ling1,YU Bin2,FANG Tai-hui2,QIAN Zhi-yu3(Guiyang Medical College,Guiyang 550004;2.Nanjing University of Traditional Chinese Medicine,Nanjing 210029;3.China Pharmaceutical University,Nanjing 210009);PROTECTIVE EFFECTS OF RADIX PSEUDOSTELLARIAE ON RAT CHRONIC HEART FAILURE AND MMPS IN LEFT VENTRICULAR TISSUE INDUCED BY CORONARY ARTERY LIGATION[J];Guizhou Science;2007-S1
10 NING Xiao-ran~1,WANG Jing-lian~1,ZHENG Wei~2,TAO Jie-mei~1,YU Chun-ying~3(1.Department of Rheumotology,the Hebei Provincial People's Hospital,Shijiazhuang 050051,China;2.Department of Orthopaedics,the Third Hospital of Shijiazhuang,Shijiazhuang 050011,China;3.Department of Traditional Chinese Medicine,the Hebei Provincial People's Hospital,Shijiazhuang 050051,China);EFFECTS OF QIANGXIN DECOCTION ON ANGIOTENSIN Ⅱ AND MYOCARDIAL ULTRASTRUCTURAL CHANGES IN RATS WITH EXPERIMENTAL MYOCARDIAL HYPERTROPHY[J];Journal of Hebei Medical University;2006-05
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Chen Min,Feng Li,Yang Jiguo,et al Zhejiang Chinese Medical University,Hangzhou(310053);The Research of CAMP’s Messenger Function in Disease[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-03
2 Ni Li1 Liu Zhibin1 Huang Guangwei2 Rao Pingfan1 (1College of Biological Sci. & Tech. Fuzhou University, Fuzhou 350002 2Almond Board of California, CA 95354, USA);The Research on Yin-Yang Nature of Almond[J];Journal of Chinese Institute of Food Science and Technology;2008-05
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