Experimental Studies on Anti-aging Actions of Total Saponins of Radix Notoginseng
QU Zeqiang, XIE Zhiguang, WANG Naiping, PAO Yunping, ZHONG Zhenguo (Guangxi College of TCM, Nanning 530001 Guangxi, China)
[Objective] To observe the anti-aging actions of total saponins of Radix Notoginseng, i.e., Panax Notoginseng saponins (PNS) on rats with Alzheimer's Disease (AD). [Methods] Among 90 Wistar rats, 15 rats aged 3 months were allocated to the youth group, 15 aged 15 months to the aged group, and other 60 aged 15 months were given with intraperitoneal injection of D-galactose and injection of ibotenic acid into bilateral Meynert nucleus basalis to establish the models of AD. After then, the surviving model rats were randomized into four groups: model control, high-dose PNS (200mg·kg-1·d-1), low-dose PNS (100 mg·kg-1·d-1) and huperzine A (0.3 mg·kg-1·d-1). Except the model group, the youth group and the aged group were given the same amount of normal saline by gavage, the other groups were treated with the designed drugs respectively for 4 weeks. After treatment, serum levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), triglyceride (TG) and cholesterol were detected. [Results] High- and low-dose PNS increased the serum levels of SOD, GSH and CAT, the differences being significance as compared with the model group (P 0.05 or P 0.01 ); high-dose PNS decreased the serum cholesterol level ( P 0.05 compared with the model group). [Conclusion] The anti-aging actions of PNS may be related to the counteraction of production of free radicals and to the decrease of serum cholesterol level.